Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA055833-03
Application #
2096939
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1994-07-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Adapala, R K; Thoppil, R J; Ghosh, K et al. (2016) Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy. Oncogene 35:314-22
Thodeti, Charles K; Matthews, Benjamin; Ravi, Arvind et al. (2009) TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res 104:1123-30
Czakó, Barbara; Kürti, László; Mammoto, Akiko et al. (2009) Discovery of potent and practical antiangiogenic agents inspired by cortistatin A. J Am Chem Soc 131:9014-9
Ostuni, Emanuele; Whitesides, George M; Ingber, Donald E et al. (2009) Using self-assembled monolayers to pattern ECM proteins and cells on substrates. Methods Mol Biol 522:183-94
Hoffmann, Martin; Chang, Hannah H; Huang, Sui et al. (2008) Noise-driven stem cell and progenitor population dynamics. PLoS One 3:e2922
Ingber, Donald E (2008) Tensegrity and mechanotransduction. J Bodyw Mov Ther 12:198-200
Ingber, Donald E (2008) Can cancer be reversed by engineering the tumor microenvironment? Semin Cancer Biol 18:356-64
Stamenovic, Dimitrije; Rosenblatt, Noah; Montoya-Zavala, Martin et al. (2007) Rheological behavior of living cells is timescale-dependent. Biophys J 93:L39-41
Wilson, Nathan R; Ty, Michael T; Ingber, Donald E et al. (2007) Synaptic reorganization in scaled networks of controlled size. J Neurosci 27:13581-9
Mammoto, Tadanori; Parikh, Samir M; Mammoto, Akiko et al. (2007) Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem 282:23910-8

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