Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA057212-04
Application #
2097967
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1993-04-01
Project End
2000-01-31
Budget Start
1996-04-23
Budget End
1997-01-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Shaikh, Saame Raza; Locascio, Daniel S; Soni, Smita P et al. (2009) Oleic- and docosahexaenoic acid-containing phosphatidylethanolamines differentially phase separate from sphingomyelin. Biochim Biophys Acta 1788:2421-6
Soni, Smita P; LoCascio, Daniel S; Liu, Yidong et al. (2008) Docosahexaenoic acid enhances segregation of lipids between : 2H-NMR study. Biophys J 95:203-14
Shaikh, Saame Raza; Cherezov, Vadim; Caffrey, Martin et al. (2006) Molecular organization of cholesterol in unsaturated phosphatidylethanolamines: X-ray diffraction and solid state 2H NMR reveal differences with phosphatidylcholines. J Am Chem Soc 128:5375-83
Roach, Charles; Feller, Scott E; Ward, Jesse A et al. (2004) Comparison of cis and trans fatty acid containing phosphatidylcholines on membrane properties. Biochemistry 43:6344-51
Shaikh, Saame Raza; Dumaual, Alfred C; Castillo, Alicia et al. (2004) Oleic and docosahexaenoic acid differentially phase separate from lipid raft molecules: a comparative NMR, DSC, AFM, and detergent extraction study. Biophys J 87:1752-66
Shaikh, Saame Raza; Cherezov, Vadim; Caffrey, Martin et al. (2003) Interaction of cholesterol with a docosahexaenoic acid-containing phosphatidylethanolamine: trigger for microdomain/raft formation? Biochemistry 42:12028-37
Armstrong, Victoria T; Brzustowicz, Michael R; Wassall, Stephen R et al. (2003) Rapid flip-flop in polyunsaturated (docosahexaenoate) phospholipid membranes. Arch Biochem Biophys 414:74-82
Siddiqui, Rafat A; Jenski, Laura J; Harvey, Kevin A et al. (2003) Cell-cycle arrest in Jurkat leukaemic cells: a possible role for docosahexaenoic acid. Biochem J 371:621-9
Shaikh, Saame Raza; Brzustowicz, Michael R; Gustafson, Noah et al. (2002) Monounsaturated PE does not phase-separate from the lipid raft molecules sphingomyelin and cholesterol: role for polyunsaturation? Biochemistry 41:10593-602
Brzustowicz, Michael R; Cherezov, Vadim; Caffrey, Martin et al. (2002) Molecular organization of cholesterol in polyunsaturated membranes: microdomain formation. Biophys J 82:285-98

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