We propose to continue the largest follow-up study of the health of African-American women yet undertaken, the Black Women's Health Study (BWHS).
The aim i s to determine the effects on breast cancer incidence (and eventually other cancers) of potential risk factors, including physical activity, obesity, alcohol, diet, oral contraceptives, and postmenopausal female hormones. Most of these factors have not been studied in black women. In addition, factors specific to African-American women, including experiences and perceptions of racism and use of hair straightening products (which is very common) will be assessed. Because prevention programs require an understanding of the determinants of risk factors, we will also assess correlates of important risk factors. The BWHS cohort was established in 1995 when 64,554 black women aged 21-69 years from all regions of the U.S. completed mail questionnaires, providing data on demographic factors, medical and reproductive history, use of oral contraceptives and other drugs, physical activity, smoking, alcohol use, diet, and other factors. Methods for following participants, collecting, processing and managing the data, and validating cancer outcomes have been developed, and results of analyses of the baseline data have been published. The first round of follow-up (every 2 years) to determine incident cancer and changes in exposures has been carried out, with a follow-up rate of 83 percent. After further cycles of follow-up through the end of the proposed grant, 600 plus cases of breast cancer will be available for analysis. Hypotheses to be assessed include whether physical activity reduces the incidence, and whether dietary fat intake and alcohol consumption increase it. African-American women suffer a greater burden of cancer morbidity than white women but there have been few studies in black women. The BWHS will contribute to the effort to improve the health of African-American women by providing insight into causes and preventives of breast cancer and other cancers and useful information for intervention programs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA058420-08S1
Application #
6494296
Study Section
Special Emphasis Panel (ZRG1 (02))
Project Start
1994-09-02
Project End
2004-07-31
Budget Start
2001-08-01
Budget End
2002-07-31
Support Year
8
Fiscal Year
2001
Total Cost
$109,499
Indirect Cost
Name
Boston University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Haddad, Stephen A; Ruiz-Narváez, Edward A; Cozier, Yvette C et al. (2018) Association of Degree of European Genetic Ancestry With Serum Vitamin D Levels in African Americans. Am J Epidemiol 187:1420-1423
Bensen, Jeannette T; Graff, Mariaelisa; Young, Kristin L et al. (2018) A survey of microRNA single nucleotide polymorphisms identifies novel breast cancer susceptibility loci in a case-control, population-based study of African-American women. Breast Cancer Res 20:45
Allott, Emma H; Geradts, Joseph; Cohen, Stephanie M et al. (2018) Frequency of breast cancer subtypes among African American women in the AMBER consortium. Breast Cancer Res 20:12
Cozier, Yvette C; Barbhaiya, Medha; Castro-Webb, Nelsy et al. (2018) A prospective study of obesity and risk of systemic lupus erythematosus (SLE) among Black women. Semin Arthritis Rheum :
Ochs-Balcom, Heather M; Shaw, Holly; Preus, Leah et al. (2018) Admixture mapping and fine-mapping of birth weight loci in the Black Women's Health Study. Hum Genet :
Arkema, Elizabeth V; Cozier, Yvette C (2018) Epidemiology of sarcoidosis: current findings and future directions. Ther Adv Chronic Dis 9:227-240
Cozier, Yvette C; Barbhaiya, Medha; Castro-Webb, Nelsy et al. (2018) Relationship of cigarette smoking and alcohol consumption to incidence of systemic lupus erythematosus in the Black Women's Health Study. Arthritis Care Res (Hoboken) :
Sponholtz, Todd R; Palmer, Julie R; Rosenberg, Lynn A et al. (2018) Exogenous Hormone Use and Endometrial Cancer in U.S. Black Women. Cancer Epidemiol Biomarkers Prev 27:558-565
Hong, Chi-Chen; Sucheston-Campbell, Lara E; Liu, Song et al. (2018) Genetic Variants in Immune-Related Pathways and Breast Cancer Risk in African American Women in the AMBER Consortium. Cancer Epidemiol Biomarkers Prev 27:321-330
Uribe-Salazar, José M; Palmer, Julie R; Haddad, Stephen A et al. (2018) Admixture mapping and fine-mapping of type 2 diabetes susceptibility loci in African American women. J Hum Genet 63:1109-1117

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