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Ramadhar, Timothy R; Beemelmanns, Christine; Currie, Cameron R et al. (2014) Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery. J Antibiot (Tokyo) 67:53-8
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Wieland Brown, Laura C; Acker, Michael G; Clardy, Jon et al. (2009) Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A 106:2549-53
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Fischbach, Michael A; Walsh, Christopher T; Clardy, Jon (2008) The evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci U S A 105:4601-8
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Mazitschek, Ralph; Patel, Vishal; Wirth, Dyann F et al. (2008) Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. Bioorg Med Chem Lett 18:2809-12
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Clardy, Jon; Brady, Sean F (2007) Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium. J Bacteriol 189:6487-9
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Schroeder, Frank C; Gibson, Donna M; Churchill, Alice C L et al. (2007) Differential analysis of 2D NMR spectra: new natural products from a pilot-scale fungal extract library. Angew Chem Int Ed Engl 46:901-4
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Junker, Lauren M; Clardy, Jon (2007) High-throughput screens for small-molecule inhibitors of Pseudomonas aeruginosa biofilm development. Antimicrob Agents Chemother 51:3582-90
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Schmitz, Katja; Haggarty, Stephen J; McPherson, Olivia M et al. (2007) Detecting binding interactions using microarrays of natural product extracts. J Am Chem Soc 129:11346-7
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Lautenschlager, Catherine; Leal, Walter S; Clardy, Jon (2007) Bombyx mori pheromone-binding protein binding nonpheromone ligands: implications for pheromone recognition. Structure 15:1148-54
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Fischbach, Michael A; Clardy, Jon (2007) One pathway, many products. Nat Chem Biol 3:353-5
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Showing the most recent 10 out of 28 publications
