|
Morrow, John K; Du-Cuny, Lei; Chen, Lu et al. (2011) Recent development of anticancer therapeutics targeting Akt. Recent Pat Anticancer Drug Discov 6:146-59
|
|
Ahad, Ali Md; Zuohe, Song; Du-Cuny, Lei et al. (2011) Development of sulfonamide AKT PH domain inhibitors. Bioorg Med Chem 19:2046-54
|
|
Meuillet, Emmanuelle J; Zuohe, Song; Lemos, Robert et al. (2010) Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther 9:706-17
|
|
Morrow, John Kenneth; Tian, Longzhang; Zhang, Shuxing (2010) Molecular networks in drug discovery. Crit Rev Biomed Eng 38:143-56
|
|
Ihle, Nathan T; Powis, Garth (2010) The biological effects of isoform-specific PI3-kinase inhibition. Curr Opin Drug Discov Devel 13:41-9
|
|
Koul, Dimpy; Shen, Ruijun; Kim, Yong-Wan et al. (2010) Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma. Neuro Oncol 12:559-69
|
|
Ihle, Nathan T; Powis, Garth (2010) Inhibitors of phosphatidylinositol-3-kinase in cancer therapy. Mol Aspects Med 31:135-44
|
|
Du-Cuny, Lei; Song, Zuohe; Moses, Sylvestor et al. (2009) Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorg Med Chem 17:6983-92
|
|
Ihle, Nathan T; Lemos, Robert; Schwartz, David et al. (2009) Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity. Mol Cancer Ther 8:94-100
|
|
Moses, Sylvestor A; Ali, M Ahad; Zuohe, Song et al. (2009) In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT. Cancer Res 69:5073-81
|
Showing the most recent 10 out of 25 publications
