Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA063071-03
Application #
2104687
Study Section
Pathology A Study Section (PTHA)
Project Start
1994-06-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Pharmacology
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Mitin, Natalia; Roberts, Patrick J; Chenette, Emily J et al. (2012) Posttranslational lipid modification of Rho family small GTPases. Methods Mol Biol 827:87-95
Vigil, Dominico; Cherfils, Jacqueline; Rossman, Kent L et al. (2010) Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat Rev Cancer 10:842-57
Madigan, James P; Bodemann, Brian O; Brady, Donita C et al. (2009) Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. Biochem J 424:153-61
Roberts, Patrick J; Mitin, Natalia; Keller, Patricia J et al. (2008) Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem 283:25150-63
Kim, Tai Young; Healy, Kevin D; Der, Channing J et al. (2008) Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration. J Biol Chem 283:32762-70
Healy, Kevin D; Hodgson, Louis; Kim, Tai-Young et al. (2008) DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog 47:326-37
Cha, Jiyoung Y; Lambert, Que T; Reuther, Gary W et al. (2008) Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis. Mol Cancer Res 6:435-45
Onesto, Cercina; Shutes, Adam; Picard, Virginie et al. (2008) Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. Methods Enzymol 439:111-29
Mitin, Natalia; Betts, Laurie; Yohe, Marielle E et al. (2007) Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Nat Struct Mol Biol 14:814-23
Shutes, Adam; Onesto, Cercina; Picard, Virginie et al. (2007) Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem 282:35666-78

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