Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA065572-02
Application #
2108606
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1995-03-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Biochemistry
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Pei, Xin-Hai; Bai, Feng; Li, Zhijun et al. (2011) Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis. Cancer Res 71:2969-77
Zhao, Shimin; Xu, Wei; Jiang, Wenqing et al. (2010) Regulation of cellular metabolism by protein lysine acetylation. Science 327:1000-4
Yan, Jun; Xiong, Yue (2010) Targeted ubiquitylation: the prey becomes predator. Mol Cell 40:853-5
Zhang, Heng; Liu, Chen-Ying; Zha, Zheng-Yu et al. (2009) TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem 284:13355-62
Kotake, Yojiro; Zeng, Yaxue; Xiong, Yue (2009) DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation. Cancer Res 69:1809-14
Andrews, P; He, Y J; Xiong, Y (2006) Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function. Oncogene 25:4534-48
Pei, Xin-Hai; Bai, Feng; Tsutsui, Tateki et al. (2004) Genetic evidence for functional dependency of p18Ink4c on Cdk4. Mol Cell Biol 24:6653-64
Bai, Feng; Pei, Xin-Hai; Godfrey, Virginia L et al. (2003) Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Mol Cell Biol 23:1269-77
Zhang, Yanping; Wolf, Gabrielle White; Bhat, Krishna et al. (2003) Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol 23:8902-12
Shumway, Stuart D; Li, Yong; Xiong, Yue (2003) 14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin. J Biol Chem 278:2089-92

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