Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA065622-04
Application #
2108675
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1994-08-07
Project End
1997-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Song, Robert X-D; Chen, Yuchai; Zhang, Zhenguo et al. (2010) Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. J Steroid Biochem Mol Biol 118:219-30
Li, Yan; Wang, Ji-Ping; Santen, Richard J et al. (2010) Estrogen stimulation of cell migration involves multiple signaling pathway interactions. Endocrinology 151:5146-56
Harvey, Jennifer A; Santen, Richard J; Petroni, Gina R et al. (2008) Histologic changes in the breast with menopausal hormone therapy use: correlation with breast density, estrogen receptor, progesterone receptor, and proliferation indices. Menopause 15:67-73
Santen, Richard J; Song, Robert X; Masamura, Shigeru et al. (2008) Adaptation to estradiol deprivation causes up-regulation of growth factor pathways and hypersensitivity to estradiol in breast cancer cells. Adv Exp Med Biol 630:19-34
Sogon, Tetsuya; Masamura, Shigeru; Hayashi, Shin-Ichi et al. (2007) Demethylation of promoter C region of estrogen receptor alpha gene is correlated with its enhanced expression in estrogen-ablation resistant MCF-7 cells. J Steroid Biochem Mol Biol 105:106-14
Yue, Wei; Fan, Ping; Wang, Jiping et al. (2007) Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells. J Steroid Biochem Mol Biol 106:102-10
Song, Robert X-D; Zhang, Zhenguo; Chen, Yucai et al. (2007) Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells. Endocrinology 148:4091-101
Song, Robert X-D; Santen, Richard J (2006) Membrane initiated estrogen signaling in breast cancer. Biol Reprod 75:9-16
Song, Robert X-D; Zhang, Zhenguo; Santen, Richard J (2005) Estrogen rapid action via protein complex formation involving ERalpha and Src. Trends Endocrinol Metab 16:347-53
Song, R X-D; Zhang, Z; Mor, G et al. (2005) Down-regulation of Bcl-2 enhances estrogen apoptotic action in long-term estradiol-depleted ER(+) breast cancer cells. Apoptosis 10:667-78

Showing the most recent 10 out of 18 publications