Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA066236-02
Application #
2109539
Study Section
Experimental Immunology Study Section (EI)
Project Start
1994-12-08
Project End
1999-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Banta, Karl L; Wang, Xinyue; Das, Phani et al. (2018) B cell lymphoma 2 (Bcl-2) residues essential for Bcl-2's apoptosis-inducing interaction with Nur77/Nor-1 orphan steroid receptors. J Biol Chem 293:4724-4734
Burger, Megan L; Leung, Kenneth K; Bennett, Margaux J et al. (2014) T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity. Elife 3:
Burger, Megan L; Xue, Ling; Sun, Yuefang et al. (2014) Premalignant PTEN-deficient thymocytes activate microRNAs miR-146a and miR-146b as a cellular defense against malignant transformation. Blood 123:4089-100
Halkias, Joanna; Melichar, Heather J; Taylor, Kayleigh T et al. (2013) Opposing chemokine gradients control human thymocyte migration in situ. J Clin Invest 123:2131-42
Thompson, Jennifer; Burger, Megan L; Whang, Hannah et al. (2010) Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis. Eur J Immunol 40:2041-9
Xue, Ling; Sun, Yuefang; Chiang, Leslie et al. (2010) Coupling of the cell cycle and apoptotic machineries in developing T cells. J Biol Chem 285:7556-65
Xue, Ling; Chiang, Leslie; He, Bo et al. (2010) FoxM1, a forkhead transcription factor is a master cell cycle regulator for mouse mature T cells but not double positive thymocytes. PLoS One 5:e9229
Thompson, Jennifer; Winoto, Astar (2008) During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain. J Exp Med 205:1029-36
Xue, Ling; Chiang, Leslie; Kang, Chulho et al. (2008) The role of the PI3K-AKT kinase pathway in T-cell development beyond the beta checkpoint. Eur J Immunol 38:3200-7
Rajpal, Arvind; Cho, Yuri A; Yelent, Biana et al. (2003) Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor. EMBO J 22:6526-36

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