Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA069632-01
Application #
2113671
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1996-05-01
Project End
2000-02-29
Budget Start
1996-05-01
Budget End
1997-02-28
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Wallecha, Anu; Wood, Laurence; Pan, Zhen-Kun et al. (2013) Listeria monocytogenes-derived listeriolysin O has pathogen-associated molecular pattern-like properties independent of its hemolytic ability. Clin Vaccine Immunol 20:77-84
Guirnalda, Patrick D; Paterson, Yvonne (2012) Vaccination with immunotherapeutic Listeria monocytogenes induces IL-17(+) ?? T cells in a murine model for HPV associated cancer. Oncoimmunology 1:822-828
Wood, Laurence M; Pan, Zhen-Kun; Seavey, Matthew M et al. (2012) The ubiquitin-like protein, ISG15, is a novel tumor-associated antigen for cancer immunotherapy. Cancer Immunol Immunother 61:689-700
Lasaro, Marcio O; Sazanovich, Marina; Giles-Davis, Wynetta et al. (2011) Active immunotherapy combined with blockade of a coinhibitory pathway achieves regression of large tumor masses in cancer-prone mice. Mol Ther 19:1727-36
Gravekamp, Claudia; Paterson, Yvonne (2010) Harnessing Listeria monocytogenes to target tumors. Cancer Biol Ther 9:257-65
Wood, Laurence M; Pan, Zhen-Kun; Shahabi, Vafa et al. (2010) Listeria-derived ActA is an effective adjuvant for primary and metastatic tumor immunotherapy. Cancer Immunol Immunother 59:1049-1058
Mustafa, Waleed; Maciag, Paulo Cesar; Pan, Zhen-kun et al. (2009) Listeria monocytogenes delivery of HPV-16 major capsid protein L1 induces systemic and mucosal cell-mediated CD4+ and CD8+ T-cell responses after oral immunization. Viral Immunol 22:195-204
Sewell, Duane A; Pan, Zhen Kun; Paterson, Yvonne (2008) Listeria-based HPV-16 E7 vaccines limit autochthonous tumor growth in a transgenic mouse model for HPV-16 transformed tumors. Vaccine 26:5315-20
Peng, Xiaohui; Treml, John; Paterson, Yvonne (2007) Adjuvant properties of listeriolysin O protein in a DNA vaccination strategy. Cancer Immunol Immunother 56:797-806
Souders, N C; Verch, T; Paterson, Y (2006) In vivo bactofection: listeria can function as a DNA-cancer vaccine. DNA Cell Biol 25:142-51

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