Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA073709-01
Application #
2011715
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1997-04-01
Project End
2000-03-31
Budget Start
1997-04-01
Budget End
1998-03-31
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Patel, Anand G; Flatten, Karen S; Peterson, Kevin L et al. (2016) Immunodetection of human topoisomerase I-DNA covalent complexes. Nucleic Acids Res 44:2816-26
Gálvez-Peralta, Marina; Flatten, Karen S; Loegering, David A et al. (2014) Context-dependent antagonism between Akt inhibitors and topoisomerase poisons. Mol Pharmacol 85:723-34
Patel, Anand G; Flatten, Karen S; Schneider, Paula A et al. (2012) Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes. J Biol Chem 287:4198-210
Litzow, M R; Peethambaram, P P; Safgren, S L et al. (2010) Phase I trial of autologous hematopoietic SCT with escalating doses of topotecan combined with CY and carboplatin in patients with relapsed or persistent ovarian or primary peritoneal carcinoma. Bone Marrow Transplant 45:490-7
Gálvez-Peralta, Marina; Hackbarth, Jennifer S; Flatten, Karen S et al. (2009) On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents. Bioorg Med Chem Lett 19:4459-62
Karp, Judith E; Flatten, Karen; Feldman, Eric J et al. (2009) Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide. Blood 113:4841-52
Lewis, Kriste A; Lilly, Kia K; Reynolds, Evelyn A et al. (2009) Ataxia telangiectasia and rad3-related kinase contributes to cell cycle arrest and survival after cisplatin but not oxaliplatin. Mol Cancer Ther 8:855-63
Molina, Julian R; Kaufmann, Scott H; Reid, Joel M et al. (2008) Evaluation of lapatinib and topotecan combination therapy: tissue culture, murine xenograft, and phase I clinical trial data. Clin Cancer Res 14:7900-8
Hackbarth, Jennifer S; Galvez-Peralta, Marina; Dai, Nga T et al. (2008) Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I. J Biol Chem 283:16711-22
Galvez-Peralta, Marina; Dai, Nga T; Loegering, David A et al. (2008) Overcoming S-phase checkpoint-mediated resistance: sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines. Mol Pharmacol 74:724-35

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