Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA074224-07
Application #
6622183
Study Section
Cell Development and Function Integrated Review Group (CDF)
Program Officer
Spalholz, Barbara A
Project Start
1997-04-18
Project End
2007-01-31
Budget Start
2003-02-01
Budget End
2004-01-31
Support Year
7
Fiscal Year
2003
Total Cost
$412,070
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Mu, Ruiling; Tat, John; Zamudio, Robert et al. (2017) CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin. Mol Cell Biol 37:
del Rincón, S V; Widschwendter, M; Sun, D et al. (2015) Cks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints. Oncogene 34:1961-7
Teixeira, Leonardo K; Reed, Steven I (2013) Ubiquitin ligases and cell cycle control. Annu Rev Biochem 82:387-414
Pan, Yen-Ru; Sun, Michael; Wohlschlegel, James et al. (2013) Cks1 enhances transcription efficiency at the GAL1 locus by linking the Paf1 complex to the 19S proteasome. Eukaryot Cell 12:1192-201
Liberal, Vasco; Martinsson-Ahlzen, Hanna-Stina; Liberal, Jennifer et al. (2012) Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins. Proc Natl Acad Sci U S A 109:2754-9
Martinsson-Ahlzen, Hanna-Stina; Liberal, Vasco; Grunenfelder, Bjorn et al. (2008) Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells. Mol Cell Biol 28:5698-709
Xu, Kui; Belunis, Charles; Chu, Wei et al. (2003) Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase. Biochem J 371:957-64
Spruck, Charles H; de Miguel, Maria P; Smith, Adrian P L et al. (2003) Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis. Science 300:647-50
Spruck, Charles H; Strohmaier, Heimo M (2002) Seek and destroy: SCF ubiquitin ligases in mammalian cell cycle control. Cell Cycle 1:250-4
Spruck, C; Strohmaier, H; Watson, M et al. (2001) A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Mol Cell 7:639-50