Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA077204-05
Application #
6704171
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Program Officer
Forry, Suzanne L
Project Start
1998-12-18
Project End
2008-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
5
Fiscal Year
2004
Total Cost
$284,820
Indirect Cost
Name
University of Arizona
Department
Type
Schools of Medicine
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Guntle, Gerald P; Jagadish, Bhumasamudram; Mash, Eugene A et al. (2012) Tumor Xenograft Response to Redox-Active Therapies Assessed by Magnetic Resonance Imaging Using a Thiol-Bearing DOTA Complex of Gadolinium. Transl Oncol 5:190-9
Sheveleva, Elena V; Landowski, Terry H; Samulitis, Betty K et al. (2012) Imexon induces an oxidative endoplasmic reticulum stress response in pancreatic cancer cells. Mol Cancer Res 10:392-400
Kim, Yon Hui; Coon, Amy; Baker, Amanda F et al. (2011) Antitumor agent PX-12 inhibits HIF-1? protein levels through an Nrf2/PMF-1-mediated increase in spermidine/spermine acetyl transferase. Cancer Chemother Pharmacol 68:405-13
James, Brian P; Staatz, William D; Wilkinson, Sarah T et al. (2009) Superoxide dismutase is regulated by LAMMER kinase in Drosophila and human cells. Free Radic Biol Med 46:821-7
Bartholomeusz, Geoffrey; Cherukuri, Paul; Kingston, John et al. (2009) In Vivo Therapeutic Silencing of Hypoxia-Inducible Factor 1 Alpha (HIF-1?) Using Single-Walled Carbon Nanotubes Noncovalently Coated with siRNA. Nano Res 2:279-291
Baker, Amanda F; Koh, Mei Y; Williams, Ryan R et al. (2008) Identification of thioredoxin-interacting protein 1 as a hypoxia-inducible factor 1alpha-induced gene in pancreatic cancer. Pancreas 36:178-86
Koh, Mei Y; Spivak-Kroizman, Taly; Venturini, Sara et al. (2008) Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha. Mol Cancer Ther 7:90-100
Powis, Garth; Kirkpatrick, D Lynn (2007) Thioredoxin signaling as a target for cancer therapy. Curr Opin Pharmacol 7:392-7
Baker, Amanda F; Dragovich, Tomislav; Tate, Wendy R et al. (2006) The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma. J Lab Clin Med 147:83-90
Engman, Lars; McNaughton, Michael; Gajewska, Malgorzata et al. (2006) Thioredoxin reductase and cancer cell growth inhibition by organogold(III) compounds. Anticancer Drugs 17:539-44

Showing the most recent 10 out of 37 publications