The relationship between anxiety and smoking in high-risk subgroups, such as patients with Post-traumatic Stress Disorder (PTSD), has received little empirical attention. Preliminary research indicates that 60% of PTSD combat veterans smoke, and that during a laboratory stressor, PTSD patients report greater smoking withdrawal symptoms in response to trauma- related Stroop cards. These results suggest that trauma-related material may serve as a cue for smoking in PTSD combat veterans. The first purpose of this proposal is to determine whether increased craving for cigarettes after Vietnam words occurs in veterans with PTSD as compared to veterans without PTSD or GAD patients, and whether PTSD patient groups experience greater relief from their symptoms, including PTSD reexperiencing and hyper-arousal symptoms after smoking. A well-established script-driven imagery procedure will be utilized to examine the effect of different scripts (disorder-related, general stress, neutral) across study groups, and the effect of nicotine on symptom reduction. The second purpose of this proposal is to explore the link between anxiety and smoking in the natural environment by comparing study groups. Subjects will monitor their smoking using an ambulatory heart rate monitor and diary. Besides potentially confirming parallel laboratory and real-world data on a relationship between anxiety and smoking, a naturalistic observation study will allow examination of whether the association between smoking and anxiety is due to other circumstances which co-occur with both anxiety and smoking. The ultimate goal of this research is to identify risk factors in subgroups of smokers who are at risk for increased smoking and difficulty in smoking cessation that could lead to important prevention and intervention efforts.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA081595-02
Application #
2896794
Study Section
Special Emphasis Panel (ZMH1-BRB-S (05))
Program Officer
Backinger, Cathy L
Project Start
1998-09-30
Project End
2002-07-31
Budget Start
1999-09-21
Budget End
2000-07-31
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Van Voorhees, Elizabeth E; Dennis, Paul A; Elbogen, Eric B et al. (2018) Characterizing anger-related affect in individuals with posttraumatic stress disorder using ecological momentary assessment. Psychiatry Res 261:274-280
Dedert, Eric A; Hicks, Terrell A; Dennis, Paul A et al. (2016) Roles of inter-individual differences and intra-individual acute elevations in early smoking lapse in people with posttraumatic stress disorder. Addict Behav 60:171-6
Liu, Yutao; Garrett, Melanie E; Dennis, Michelle F et al. (2015) An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans. PLoS One 10:e0119998
Vrana, Scott R; Calhoun, Patrick S; Dennis, Michelle F et al. (2015) Acoustic startle and prepulse inhibition predict smoking lapse in posttraumatic stress disorder. J Psychopharmacol 29:1070-6
Volz, Angela R; Dennis, Paul A; Dennis, Michelle F et al. (2014) The role of daily hassles and distress tolerance in predicting cigarette craving during a quit attempt. Nicotine Tob Res 16:872-5
Van Voorhees, Elizabeth E; Dennis, Michelle F; Calhoun, Patrick S et al. (2014) Association of DHEA, DHEAS, and cortisol with childhood trauma exposure and post-traumatic stress disorder. Int Clin Psychopharmacol 29:56-62
Wilson, Sarah M; Dedert, Eric A; Dennis, Paul A et al. (2014) Do ethnicity and gender moderate the influence of posttraumatic stress disorder on time to smoking lapse? Addict Behav 39:1163-7
Dedert, Eric A; Dennis, Paul A; Swinkels, Cindy M et al. (2014) Ecological momentary assessment of posttraumatic stress disorder symptoms during a smoking quit attempt. Nicotine Tob Res 16:430-6
Van Voorhees, Elizabeth E; Dennis, Michelle F; McClernon, F Joseph et al. (2013) The association of dehydroepiandrosterone and dehydroepiandrosterone sulfate with anxiety sensitivity and electronic diary negative affect among smokers with and without posttraumatic stress disorder. J Clin Psychopharmacol 33:556-60
Vrana, Scott R; Calhoun, Patrick S; McClernon, F Joseph et al. (2013) Effects of smoking on the acoustic startle response and prepulse inhibition in smokers with and without posttraumatic stress disorder. Psychopharmacology (Berl) 230:477-85

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