Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA085693-04
Application #
6633670
Study Section
Radiation Study Section (RAD)
Program Officer
Pelroy, Richard
Project Start
2000-07-01
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
4
Fiscal Year
2003
Total Cost
$195,750
Indirect Cost
Name
Louisiana State University Hsc Shreveport
Department
Physiology
Type
Schools of Medicine
DUNS #
095439774
City
Shreveport
State
LA
Country
United States
Zip Code
71103
Wright, Douglas G; Castore, Reneau; Shi, Runhua et al. (2017) Mycobacterium tuberculosis and Mycobacterium marinum non-homologous end-joining proteins can function together to join DNA ends in Escherichia coli. Mutagenesis 32:245-256
Malyarchuk, Svitlana; Castore, Reneau; Shi, Runhua et al. (2013) Artemis is required to improve the accuracy of repair of double-strand breaks with 5'-blocked termini generated from non-DSB-clustered lesions. Mutagenesis 28:357-66
Shao, Zhengping; Davis, Anthony J; Fattah, Kazi R et al. (2012) Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination. DNA Repair (Amst) 11:310-6
Castore, Reneau; Hughes, Cameron; Debeaux, Austin et al. (2011) Mycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate. Mutagenesis 26:795-803
Sage, Evelyne; Harrison, Lynn (2011) Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survival. Mutat Res 711:123-33
Wright, Douglas; DeBeaux, Austin; Shi, Runhua et al. (2010) Characterization of the roles of the catalytic domains of Mycobacterium tuberculosis ligase D in Ku-dependent error-prone DNA end joining. Mutagenesis 25:473-81
Kha, Diem T; Wang, Guliang; Natrajan, Nithya et al. (2010) Pathways for double-strand break repair in genetically unstable Z-DNA-forming sequences. J Mol Biol 398:471-80
Malyarchuk, Svitlana; Castore, Reneau; Harrison, Lynn (2009) Apex1 can cleave complex clustered DNA lesions in cells. DNA Repair (Amst) 8:1343-54
Malyarchuk, Svitlana; Castore, Reneau; Harrison, Lynn (2008) DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining. Nucleic Acids Res 36:4872-82
Malyarchuk, Svitlana; Wright, Douglas; Castore, Reneau et al. (2007) Expression of Mycobacterium tuberculosis Ku and Ligase D in Escherichia coli results in RecA and RecB-independent DNA end-joining at regions of microhomology. DNA Repair (Amst) 6:1413-24

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