This project proposes to increase understanding of the design and function of cigarettes through analysis of internal tobacco industry documents. Internal documents allow unprecedented access to manufacturer knowledge and intentions regarding aspects of product development. The first objective of this project is to examine the importance of smoke chemistry and sensory cues in determining smoke delivery, smoke exposure, and subjective response. This research is critical to understanding physiological, psychopharmacological, and health effects of tobacco smoke, and their role in the development of smoking behaviors, dependence, and disease. The second objective of this project is to examine the means by which cigarettes may be targeted toward specific smoker populations, and to determine the effects of targeted product development. Effects of product targeting may include greater neurobiological or physiological response, increased motivation to smoke, increased initiation and dependence, increased exposure, and reduced likelihood of quitting. The final objective of this project is to assess internal industry product measures, and identify research needs, with regard to understanding and evaluating emerging """"""""potential reduced-exposure products"""""""" (PREPs) and conventional products, especially """"""""low yield"""""""" cigarettes. The need for more effective tools for product evaluation is well established. PREPs and other new products warrant special consideration not only because of their potential for unique behavioral effects and product risk, but also due to the explicit and implied health claims commonly associated with them. Overall, comprehensive analysis of tobacco smoke delivery, brand differences, and effects has been limited by the lack of information regarding the nature and role of specific smoke constituents, smoke chemistry, and sensory cues; and product driven changes in perception, behavior, patterns of deposition, and physiological response. Findings from this project may have significant implications for treatment efforts as well as development of effective policy and strategies for product regulation. ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA087477-06
Application #
6945160
Study Section
Special Emphasis Panel (ZRG1-HOP-J (90))
Program Officer
Bloch, Michele H
Project Start
2000-09-01
Project End
2008-06-30
Budget Start
2005-09-01
Budget End
2006-06-30
Support Year
6
Fiscal Year
2005
Total Cost
$438,798
Indirect Cost
Name
Harvard University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Alpert, Hillel R; Agaku, Israel T; Connolly, Gregory N (2016) A study of pyrazines in cigarettes and how additives might be used to enhance tobacco addiction. Tob Control 25:444-50
Agaku, Israel T; Vardavas, Constantine I; Ayo-Yusuf, Olalekan A et al. (2014) Gender and racial differences in smoking of long/ultra-long and king size cigarettes among U.S. adult smokers, NHANES 1999-2012. Drug Alcohol Depend 136:28-35
Sokol, Natasha A; Kennedy, Ryan David; Connolly, Gregory N (2014) The role of cocoa as a cigarette additive: opportunities for product regulation. Nicotine Tob Res 16:984-91
Alpert, Hillel R; Christiani, David C; Orav, E John et al. (2014) Effectiveness of the cigarette ignition propensity standard in preventing unintentional residential fires in Massachusetts. Am J Public Health 104:e56-61
Connolly, Gregory N; Alpert, Hillel R (2014) Has the tobacco industry evaded the FDA's ban on 'Light' cigarette descriptors? Tob Control 23:140-5
Agaku, Israel T; Vardavas, Constantine I; Connolly, Gregory N (2014) Cigarette rod length and its impact on serum cotinine and urinary total NNAL levels, NHANES 2007-2010. Nicotine Tob Res 16:100-7
Agaku, Israel T; Ayo-Yusuf, Olalekan A; Vardavas, Constantine I et al. (2014) Predictors and patterns of cigarette and smokeless tobacco use among adolescents in 32 countries, 2007-2011. J Adolesc Health 54:47-53
Agaku, Israel T; Vardavas, Constantine I; Connolly, Gregory (2013) Proposed cutoff for identifying adult smokeless tobacco users with urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonol: an aggregated analysis of NHANES 2007-2010 data. Nicotine Tob Res 15:1956-61
Kennedy, Ryan David; Millstein, Rachel A; Rees, Vaughan W et al. (2013) Tobacco industry strategies to minimize or mask cigarette smoke: opportunities for tobacco product regulation. Nicotine Tob Res 15:596-602
Agaku, Israel T; Ayo-Yusuf, Olalekan A; Vardavas, Constantine I et al. (2013) Use of conventional and novel smokeless tobacco products among US adolescents. Pediatrics 132:e578-86

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