This application describes a planned cohort study of 80,000 white and 45,000 black adult Seventh-day Adventists, enrolled from across the U.S. Questions not easily addressed by other study populations, can be answered. Taking advantage of the unusual dietary habits of Adventists, the special focus of this application is an association between soy intake, calcium intake, and cancers of the breast, prostate and colon. About half of black and white Adventists consume similar quantities of soy to that used in China or Singapore. Adventists also have a wide variance in intake of calcium. The increasing use of soy and calcium supplements by the American population needs further evidential support. Another strength of the proposed research is the proven ability to enroll and follow a large and cooperative cohort of black Adventists. The very high incidence and mortality ascribed to prostate cancer in black men may be associated with their dietary habits. Subjects will be enrolled church by church using a pretested plan whereby institutional media and respected members at individual churches promote the study. Subjects will complete a comprehensive questionnaire which is already developed and pretested. Cancer surveillance during follow-up will be by matching with state tumor registries where possible, matching with the National Death Index, and by obtaining and coding hospitalization records as necessary. Calibration studies in both black and white Adventists will allow bias correction. We believe that it is important to also gather blood, urine and subcutaneous fat from the subjects, and have a largely pretested plan to accomplish this. This will be further tested for feasibility at a location away from Loma Linda during Year 0 1 of the present study. The Adventist population has been cooperative with epidemiologic research for many years and has some unusual strengths as a research population, including the virtual absence of confounding by tobacco and alcohol, the wide range of dietary habits and the widespread use of soy products. They have made important contributions to the understanding of diet and chronic disease in the past. This larger study will provide much greater statistical power, more accurate and documented exposure assessment, and will also include a large cohort of black Adventists.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA094594-04
Application #
6777630
Study Section
Subcommittee G - Education (NCI)
Program Officer
Hartmuller, Virginia W
Project Start
2001-09-25
Project End
2006-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
4
Fiscal Year
2004
Total Cost
$3,773,027
Indirect Cost
Name
Loma Linda University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
009656273
City
Loma Linda
State
CA
Country
United States
Zip Code
92350
Sakamoto, Rosario; Thorpe, D; Knutsen, R et al. (2018) Ethnic Variations in Serum 25(OH)D Levels and Bone Ultrasound Attenuation Measurements in Blacks and Whites. J Racial Ethn Health Disparities 5:439-448
Tantamango-Bartley, Yessenia; Knutsen, Synnove F; Jaceldo-Siegl, Karen et al. (2017) Independent associations of dairy and calcium intakes with colorectal cancers in the Adventist Health Study-2 cohort. Public Health Nutr 20:2577-2586
Kahleova, Hana; Lloren, Jan Irene; Mashchak, Andrew et al. (2017) Meal Frequency and Timing Are Associated with Changes in Body Mass Index in Adventist Health Study 2. J Nutr 147:1722-1728
Morton, Kelly R; Lee, Jerry W; Martin, Leslie R (2017) Pathways from Religion to Health: Mediation by Psychosocial and Lifestyle Mechanisms. Psycholog Relig Spiritual 9:106-117
Sonderman, Jennifer S; Bethea, Traci N; Kitahara, Cari M et al. (2016) Multiple Myeloma Mortality in Relation to Obesity Among African Americans. J Natl Cancer Inst 108:
Ford, Patricia A; Jaceldo-Siegl, Karen; Lee, Jerry W et al. (2016) Trans fatty acid intake is related to emotional affect in the Adventist Health Study-2. Nutr Res 36:509-17
Tonstad, Serena; Jaceldo-Siegl, Karen; Messina, Mark et al. (2016) The association between soya consumption and serum thyroid-stimulating hormone concentrations in the Adventist Health Study-2. Public Health Nutr 19:1464-70
Penniecook-Sawyers, Jason A; Jaceldo-Siegl, Karen; Fan, Jing et al. (2016) Vegetarian dietary patterns and the risk of breast cancer in a low-risk population. Br J Nutr 115:1790-7
Fraser, Gary E (2016) The Vegetarian Advantage: Its Potential for the Health of Our Planet, Our Livestock, and Our Neighbors! Forsch Komplementmed 23:66-8
Charlemagne-Badal, Sherma J; Lee, Jerry W (2016) Religious Social Support and Hypertension Among Older North American Seventh-Day Adventists. J Relig Health 55:709-28

Showing the most recent 10 out of 67 publications