Electron Paramagnetic Resonance (EPR Oxygen Images (EPROI) have been shown to provide quantitative localized PO2 images of animal tumors including several in syngeneic mice, and in rats, and rabbits. The oxygen broadening of narrow EPR spectral lines report the PO2 with 1-3 torr resolution in each 1mm3 image voxeL This work has shown i) the first co-localized correlation between an oxygen image and a point oxygen measurement technique (Oxylite) 2) independent, statistically significant sharpening of the 50% tumor control dose with the addition of the information provided by the fraction of EPROI voxels less than io torr (HFio) 3) co-registration of pimonidazole images nth EPROI PO2 and 4) significant spatial correlation of VEOF and EPROI based HEw. We propose the following specific aims for the given cycle: i) Determining the relation between the localized oxygen information from the EPROI and pimonidazole retention and induction of hypoxia proteins, 2) Treatment of murine tumors to TCDSO after oxygen images and determining the predictive effectiveness of the HFio and other EPROT tumor statistics.

Public Health Relevance

This work continues the investigation of a new technique to predict cure likelihood of the radiation of cancers and investigate the use of the technique to improve the cure of cancers with radiation. The technique involves a non-invasive electron magnetic resonance image of animal tumors after the injection of a non-toxic compound which reports through its electron magnetic resonance spectrum, the amount of oxygen in each of the 1mm3 volumes of a tumor. This eventually will be developed for human tumor measurements,

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA098575-05A1
Application #
7582532
Study Section
Radiation Therapeutics and Biology Study Section (RTB)
Program Officer
Croft, Barbara
Project Start
2003-06-01
Project End
2011-05-31
Budget Start
2009-06-08
Budget End
2010-05-31
Support Year
5
Fiscal Year
2009
Total Cost
$273,274
Indirect Cost
Name
University of Chicago
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Boris, Epel; Sundramoorthy, Subramanian V; Halpern, Howard J (2017) 250 MHz passive Q-modulator for reflection resonators. Concepts Magn Reson Part B Magn Reson Eng 47B:
Epel, Boris; Sundramoorthy, Subramanian V; Krzykawska-Serda, Martyna et al. (2017) Imaging thiol redox status in murine tumors in vivo with rapid-scan electron paramagnetic resonance. J Magn Reson 276:31-36
Shi, Yilin; Quine, Richard W; Rinard, George A et al. (2017) Triarylmethyl Radical OX063d24 Oximetry: Electron Spin Relaxation at 250 MHz and RF Frequency Dependence of Relaxation and Signal-to-Noise. Adv Exp Med Biol 977:327-334
Rinard, George A; Quine, Richard W; Buchanan, Laura A et al. (2017) Resonators for In Vivo Imaging: Practical Experience. Appl Magn Reson 48:1227-1247
Sundramoorthy, Subramanian V; Epel, Boris; Halpern, Howard J (2017) A Pulse EPR 25 mT magnetometer with 10ppm resolution. Appl Magn Reson 48:805-811
Nakagawa, Kouichi; Epel, Boris (2017) Investigating the Distribution of Stable Paramagnetic Species in an Apple Seed Using X-Band EPR and EPR Imaging. J Oleo Sci 66:315-319
Eaton, Sandra S; Shi, Yilin; Woodcock, Lukas et al. (2017) Rapid-scan EPR imaging. J Magn Reson 280:140-148
Epel, Boris; Maggio, Matt; Pelizzari, Charles et al. (2017) Electron Paramagnetic Resonance pO2 Image Tumor Oxygen-Guided Radiation Therapy Optimization. Adv Exp Med Biol 977:287-296
Rahimi, Robabeh; Halpern, Howard J; Takui, Takeji (2017) In Vivo EPR Resolution Enhancement Using Techniques Known from Quantum Computing Spin Technology. Adv Exp Med Biol 977:335-339
Kuzhelev, Andrey A; Tormyshev, Victor M; Rogozhnikova, Olga Yu et al. (2017) Triarylmethyl Radicals: EPR Study of 13C Hyperfine Coupling Constants. Z Phys Chem (N F) 231:777-794

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