Abstract

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  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA098779-06
Application #
7161739
Study Section
Special Emphasis Panel (ZRG1-CAMP (01))
Program Officer
Spalholz, Barbara A
Project Start
2003-01-23
Project End
2008-01-28
Budget Start
2007-01-01
Budget End
2008-01-28
Support Year
6
Fiscal Year
2007
Total Cost
$327,004
Indirect Cost

  Institution

Name
Thomas Jefferson University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107

  Publications

Danilo, Christiane; Gutierrez-Pajares, Jorge L; Mainieri, Maria Antonietta et al. (2013) Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development. Breast Cancer Res 15:R87
Trimmer, Casey; Bonuccelli, Gloria; Katiyar, Sanjay et al. (2013) Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activation. Am J Pathol 182:992-1004
Capparelli, Claudia; Chiavarina, Barbara; Whitaker-Menezes, Diana et al. (2012) CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, ""fueling"" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle 11:3599-610
Carito, Valentina; Bonuccelli, Gloria; Martinez-Outschoorn, Ubaldo E et al. (2012) Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth. Cell Cycle 11:3403-14
Guido, Carmela; Whitaker-Menezes, Diana; Lin, Zhao et al. (2012) Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth. Oncotarget 3:798-810
Sotgia, Federica; Martinez-Outschoorn, Ubaldo E; Howell, Anthony et al. (2012) Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms. Annu Rev Pathol 7:423-67
Chiavarina, Barbara; Martinez-Outschoorn, Ubaldo E; Whitaker-Menezes, Diana et al. (2012) Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1? and HIF2? in tumor-associated fibroblasts and human breast cancer cells. Cell Cycle 11:3280-9
Capparelli, Claudia; Guido, Carmela; Whitaker-Menezes, Diana et al. (2012) Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle 11:2285-302
Capparelli, Claudia; Whitaker-Menezes, Diana; Guido, Carmela et al. (2012) CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle 11:2272-84
Mercier, Isabelle; Camacho, Jeanette; Titchen, Kanani et al. (2012) Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug. Am J Pathol 181:278-93

Showing the most recent 10 out of 80 publications