Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA001533-21
Application #
2116444
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1981-06-01
Project End
1997-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Le Naour, Morgan; Akgün, Eyup; Yekkirala, Ajay et al. (2013) Bivalent ligands that target ? opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance. J Med Chem 56:5505-13
Yekkirala, Ajay S; Kalyuzhny, Alexander E; Portoghese, Philip S (2013) An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands. ACS Chem Biol 8:1412-6
Le Naour, Morgan; Lunzer, Mary M; Powers, Mike D et al. (2012) Opioid activity of spinally selective analogues of N-naphthoyl-ýý-naltrexamine in HEK-293 cells and mice. J Med Chem 55:670-7
Berg, Kelly A; Rowan, Matthew P; Gupta, Achla et al. (2012) Allosteric interactions between ýý and ýý opioid receptors in peripheral sensory neurons. Mol Pharmacol 81:264-72
Wise, Laura E; Premaratne, Ishani D; Gamage, Thomas F et al. (2012) l-theanine attenuates abstinence signs in morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in mice. Pharmacol Biochem Behav 103:245-52
Metcalf, Matthew D; Yekkirala, Ajay S; Powers, Michael D et al. (2012) The ? opioid receptor agonist SNC80 selectively activates heteromeric ?-? opioid receptors. ACS Chem Neurosci 3:505-9
Yekkirala, Ajay S; Banks, Matthew L; Lunzer, Mary M et al. (2012) Clinically employed opioid analgesics produce antinociception via ?-? opioid receptor heteromers in Rhesus monkeys. ACS Chem Neurosci 3:720-7
Aceto, Mario D; Harris, Louis S; Negus, S Stevens et al. (2012) MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys. Int J Med Chem 2012:327257
Yekkirala, Ajay S; Lunzer, Mary M; McCurdy, Christopher R et al. (2011) N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of ýý/kappa-opioid heteromers. Proc Natl Acad Sci U S A 108:5098-103
Ansonoff, Michael A; Portoghese, Philip S; Pintar, John E (2010) Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands. Psychopharmacology (Berl) 210:161-8

Showing the most recent 10 out of 29 publications