Comparatively little is known about the ways in which behavioral factors themselves may influence the time course and extent of tolerance to behavioral effects of drugs. This project will attempt to more fully characterize the importance of behavioral factors during chronic administration of modulators at GABA and NMDA receptor sites, locations associated with activity for anxiolytics and psychotomimetics that are widely used on a chronic basis. The project will focus on operant behavior that is maintained (reinforced) by delivery of food and solutions of water & sucrose. This project is intended specifically to study influences on tolerance of: 1. Response Cost - Experiments will study influences on tolerance by drug-produced changes in reinforcer frequency for varied response requirements, reinforcer magnitudes, and reinforcer types. 2. Operant Discriminations - Experiments will study influences on tolerance by discriminative properties of both the subjective effects of a drug as well as the environment in which the drug is chronically administered. Additionally, """"""""multi-chamber"""""""" procedures will study generalization of those discriminative effects to performance of the same subjects in different circumstances.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA001987-23
Application #
6868941
Study Section
Special Emphasis Panel (ZRG1-BBBP-1 (01))
Program Officer
Schnur, Paul
Project Start
1991-07-19
Project End
2007-02-28
Budget Start
2005-03-01
Budget End
2007-02-28
Support Year
23
Fiscal Year
2005
Total Cost
$292,339
Indirect Cost
Name
Mercer University Macon
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
065365041
City
Macon
State
GA
Country
United States
Zip Code
31207
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Smith, J B (1990) Effects of fixed-ratio requirement on observed tolerance to decreased responding by clonidine. Pharmacol Biochem Behav 36:993-5
Smith, J B (1987) Effects of fixed-interval duration on the development of tolerance to decreased responding by l-nantradol. Psychopharmacology (Berl) 91:127-30

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