A series of studies are proposed to investigate the biological basis of individual differences in responses to drugs of abuse in humans. Although it is widely recognized that individuals differ in their responses to drugs, little is known about the biological mechanisms underlying these differences. The proposed studies will focus on the central nervous system effects of hormones and their potential interactions with drugs of abuse. The first series of studies will assess the effects of ovarian hormones and their interactions with psychoactive drugs in women. These studies are designed to investigate the direct mood-altering and behavioral effects of estrogen and progesterone, and the interactions of these hormones with psychoactive drugs. The second series of studies is designed to assess the effects of glucocorticoids alone and on responses to d-amphetamine. These studies are based on evidence from laboratory animals indicating that stress hormones, in particular glucocorticoids, enhance the reinforcing effects of stimulant drugs. The proposed studies will investigate the direct mood-altering and behavioral effects of exogenously administered hydrocortisone in healthy human volunteers, and explore the interactions between cortisol levels and responses to drugs. In the final proposed study we will investigate the biological basis of the stimulant-like effects experienced by some individuals after ingestion of ethanol. Together, the studies will extend our understanding of the source of individual differences in responses to abused drugs, and they will further our knowledge of the interactions of drugs and hormones in the brain.
| Doss, Manoj K; Weafer, Jessica; Ruiz, Nicholas A et al. (2018) Alcohol and pharmacologically similar sedatives impair encoding and facilitate consolidation of both recollection and familiarity in episodic memory. Cogn Neurosci 9:89-99 |
| de Wit, Harriet; Epstein, David H; Preston, Kenzie L (2018) Does human language limit translatability of clinical and preclinical addiction research? Neuropsychopharmacology 43:1985-1988 |
| Crane, Natania A; Gorka, Stephanie M; Weafer, Jessica et al. (2018) Neural activation to monetary reward is associated with amphetamine reward sensitivity. Neuropsychopharmacology 43:1738-1744 |
| Doss, Manoj K; Weafer, Jessica; Gallo, David A et al. (2018) MDMA Impairs Both the Encoding and Retrieval of Emotional Recollections. Neuropsychopharmacology 43:791-800 |
| Bershad, Anya K; Miller, Melissa A; Norman, Greg J et al. (2018) Effects of opioid- and non-opioid analgesics on responses to psychosocial stress in humans. Horm Behav 102:41-47 |
| Vena, Ashley; King, Andrea; Lee, Royce et al. (2018) Intranasal Oxytocin Does Not Modulate Responses to Alcohol in Social Drinkers. Alcohol Clin Exp Res 42:1725-1734 |
| de Wit, Harriet; Sayette, Michael (2018) Considering the context: social factors in responses to drugs in humans. Psychopharmacology (Berl) 235:935-945 |
| Van Hedger, Kathryne; Bershad, Anya K; de Wit, Harriet (2017) Pharmacological challenge studies with acute psychosocial stress. Psychoneuroendocrinology 85:123-133 |
| Childs, Emma; Lutz, Joseph A; de Wit, Harriet (2017) Dose-related effects of delta-9-THC on emotional responses to acute psychosocial stress. Drug Alcohol Depend 177:136-144 |
| Cryan, John F; de Wit, Harriet (2017) Special issue: recognizing the lifetime scientific contributions of Athina Markou. Psychopharmacology (Berl) 234:1311-1313 |
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