An important facet of stimulant drug use is that the drug effects can become conditioned to drug taking situations so that even during periods of abstinence exposure to such situations can trigger drug like reactions and provoked craving. In an effort to develop a more fundamental understanding of the drug conditioning process an animal model will be used which will permit a detailed characterization of the behavioral and neurochemical mechanisms which mediate drug conditioning. The animal preparation utilizes a lesion induced hemispheric dopamine asymmetry. When rodents with this asymmetry are given dopamine agonist stimulant drugs they uniformly exhibit rotational behavior. In conventional animal behavior models the specific drug induced response is frequently idiosyncratic. The consistency of the drug induced behavioral responses in the model used in this proposal permits a critical element in the conditioning process to be specified across treatment groups, namely, the unconditioned response. With this enhanced control over conditioning variables, this proposal will (a) determine the relationship of drug history to the intensity of the conditioned drug response, (b) explore methodologies which may attenuate the conditioned response, (c) examine conditioning interactions between drugs and (d) specify neurochemical correlates of the unconditioned and conditioned drug response.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA005366-02
Application #
3211702
Study Section
(SRCD)
Project Start
1987-09-30
Project End
1990-08-31
Budget Start
1988-09-01
Budget End
1989-08-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Upstate Medical University
Department
Type
Schools of Medicine
DUNS #
058889106
City
Syracuse
State
NY
Country
United States
Zip Code
13210
de Matos, Liana Wermelinger; Carey, Robert J; Carrera, Marinete Pinheiro (2010) Apomorphine conditioning and sensitization: the paired/unpaired treatment order as a new major determinant of drug conditioned and sensitization effects. Pharmacol Biochem Behav 96:317-24
Carey, Robert J; Damianopoulos, Ernest N; Shanahan, Arielle B (2009) Cocaine conditioning: reversal by autoreceptor dose levels of 8-OHDPAT. Pharmacol Biochem Behav 91:447-52
Carey, Robert J; Damianopoulos, Ernest N; Shanahan, Arielle B (2008) Cocaine conditioned behavior: a cocaine memory trace or an anti-habituation effect. Pharmacol Biochem Behav 90:625-31
Muller, C P; Carey, R J; Wilkisz, M et al. (2008) Acute anxiolytic effects of cocaine: the role of test latency and activity phase. Pharmacol Biochem Behav 89:218-26
Pum, M E; Carey, R J; Huston, J P et al. (2008) Role of medial prefrontal, entorhinal, and occipital 5-HT in cocaine-induced place preference and hyperlocomotion: evidence for multiple dissociations. Psychopharmacology (Berl) 201:391-403
Pum, M; Carey, R J; Huston, J P et al. (2007) Dissociating effects of cocaine and d-amphetamine on dopamine and serotonin in the perirhinal, entorhinal, and prefrontal cortex of freely moving rats. Psychopharmacology (Berl) 193:375-90
Muller, Christian P; Carey, Robert J; Huston, Joseph P et al. (2007) Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors. Prog Neurobiol 81:133-78
Dias, Flavia Regina Cruz; Carey, Robert J; Carrera, Marinete Pinheiro (2006) Conditioned locomotion induced by unilateral intrastriatal administration of apomorphine: D(2) receptor activation is critical but not the expression of the unconditioned response. Brain Res 1083:85-95
Carey, Robert J; Damianopoulos, Ernest N (2006) Cocaine conditioning and sensitization: the habituation factor. Pharmacol Biochem Behav 84:128-33
Muller, Christian P; Carey, Robert J (2006) Intracellular 5-HT 2C-receptor dephosphorylation: a new target for treating drug addiction. Trends Pharmacol Sci 27:455-8

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