We plan to use this adoption sample in which significant genetic, environmental, and gene-environment factors for drug abuse vulnerability have been found in an association study using candidate genes which have been implicated in substance abuse. We predict that the inclusion in the association analysis of information available through the adoption paradigm about environmental and gene-environment interaction effects will increase the efficiency of detecting gene-behavior associations. Specific goals for this proposed continuation include: 1. Conducting a 4-year follow-up of the adoptee sample of 95 male and 102 female subjects to achieve better ascertainment of drug abuse in the sample and to evaluate better the effects of other likely genetic sources of drug abuse vulnerability such as biologic parent drug abuse. 2. Collect blood samples from adoptees, extract DNA and use to determine candidate gene association with drug abuse/dependency and other genetically determined behaviors which increase drug abuse vulnerability such as conduct disorder. 3. Efficiency of regression models which include environmental factors to detect association will be tested. This study could lead the way to the use of large pools of adoptees to detect association more effectively since environmental and gene- environment factors can be included in the analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA005821-08
Application #
2668128
Study Section
Drug Abuse Epidemiology and Prevention Research Review Committee (DAPA)
Program Officer
Conway, Kevin P
Project Start
1989-08-01
Project End
1999-02-28
Budget Start
1998-03-01
Budget End
1999-02-28
Support Year
8
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Iowa
Department
Psychiatry
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Paradiso, Sergio; Caspers, Kristin; Tranel, Daniel et al. (2011) Cognition and nondysphoric depression among adoptees at high risk for psychopathology. Compr Psychiatry 52:498-506
Bakermans-Kranenburg, Marian J; van IJzendoorn, Marinus H; Caspers, Kristin et al. (2011) DRD4 genotype moderates the impact of parental problems on unresolved loss or trauma. Attach Hum Dev 13:253-69
Caspers, Kristin M; Arndt, Stephan (2010) Birth Outcomes, Lifetime Alcohol Dependence and Cognition in Middle Adulthood. J Addict Res Ther 1:
van IJzendoorn, Marinus H; Caspers, Kristin; Bakermans-Kranenburg, Marian J et al. (2010) Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma. Biol Psychiatry 68:405-7
Caspers, Kristin; Arndt, Stephan; Yucuis, Rebecca et al. (2010) Effects of alcohol- and cigarette-use disorders on global and specific measures of cognition in middle-age adults. J Stud Alcohol Drugs 71:192-200
Caspers, Kristin M; Paradiso, Sergio; Yucuis, Rebecca et al. (2009) Association between the serotonin transporter promoter polymorphism (5-HTTLPR) and adult unresolved attachment. Dev Psychol 45:64-76
Spinks, Ruth; McKirgan, Lowell W; Arndt, Stephan et al. (2009) IQ estimate smackdown: comparing IQ proxy measures to the WAIS-III. J Int Neuropsychol Soc 15:590-6
Caspers, Kristin M; Yucuis, Rebecca; McKirgan, Lowell M et al. (2009) Lifetime substance misuse and 5-year incidence rates of emergent health problems among middle-aged adults. J Addict Dis 28:320-31
Caspers, Kristin; Yucuis, Rebecca; Troutman, Beth et al. (2007) A sibling adoption study of adult attachment: the influence of shared environment on attachment states of mind. Attach Hum Dev 9:375-91
Spinks, Ruth; Caspers, Kristin; Langbehn, Doug et al. (2007) Co-morbid health conditions at mid-life in the Iowa adoptees. Addict Behav 32:991-1002

Showing the most recent 10 out of 24 publications