Progressive weight loss and wasting are common in HIV disease. The causes of wasting in HIV infection included reduced dietary intake, malabsorption and ineffective metabolism of nutrients. It is likely that the causes of wasting differ between drug abusers and non-drug abusers because of differences in diet and metabolism. There is little information on the natural history of HIV infection, including nutritional status and wasting, in HIV-positive drug abusers. This project will study the nutritional status and causes of wasting in HIV-positive drug abusers in the Hispanic community. Emphasis will be placed on the early stages of injection when malnutrition is most amenable to correction.. Recruitment of women will receive high priority. Three groups will be studied: Hispanic HIV-positive drug abusers, Hispanic HIV-negative drug abusers and Hispanic HIV-positive non-drug abusers. The three groups will be followed every 6 months for three years during which they will be examined for changes in nutritional, immunological, and clinical status. Periodic measures of dietary intake, body composition, energy expenditure, serum vitamin levels, immunologic status, gastrointestinal function, functional status, and quality of life will be taken as the clinical course of the disease is tracked. Identify the causes of weight loss and wasting at different periods in the course of HIV disease progression will help in the design of targeted nutrition interventions that are appropriate to the drug abusing, HIV-infected population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA011598-02
Application #
6137821
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Khalsa, Jagjitsingh H
Project Start
1999-01-01
Project End
2003-12-31
Budget Start
2000-01-01
Budget End
2000-12-31
Support Year
2
Fiscal Year
2000
Total Cost
$590,965
Indirect Cost
Name
Tufts University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Kapulsky, Leonid; Tang, Alice M; Forrester, Janet E (2015) Food insecurity, depression, and social support in HIV-infected Hispanic individuals. J Immigr Minor Health 17:408-13
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Forrester, Janet E; Sztam, Kevin A (2011) Micronutrients in HIV/AIDS: is there evidence to change the WHO 2003 recommendations? Am J Clin Nutr 94:1683S-1689S
Tang, Alice M; Forrester, Janet E; Spiegelman, Donna et al. (2010) Heavy injection drug use is associated with lower percent body fat in a multi-ethnic cohort of HIV-positive and HIV-negative drug users from three U.S. cities. Am J Drug Alcohol Abuse 36:78-86
Hendricks, Kristy M; Erzen, Heather D; Wanke, Christine A et al. (2010) Nutrition issues in the HIV-infected injection drug user: findings from the nutrition for healthy living cohort. J Am Coll Nutr 29:136-43
Wang, Erica T; de Koning, Lawrence; Kanaya, Alka M (2010) Higher protein intake is associated with diabetes risk in South Asian Indians: the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA) study. J Am Coll Nutr 29:130-5
Forrester, Janet E; Wang, Xiang D; Knox, Tamsin A et al. (2009) Factors associated with serum retinol, alpha-tocopherol, carotenoids, and selenium in Hispanics with problems of HIV, chronic hepatitis C, and drug use. J Public Health Policy 30:285-99
Hendricks, Kristy; Gorbach, Sherwood (2009) Nutrition issues in chronic drug users living with HIV infection. Addict Sci Clin Pract 5:16-23
Forrester, J E; McGovern, B H; Rhee, M S et al. (2009) The individual and combined influence of HIV and hepatitis C virus on dyslipidaemia in a high-risk Hispanic population. HIV Med 10:555-63

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