The combination of cocaine abuse and HIV infection represents a unique challenge to both researchers and health professionals. Both HIV and cocaine abuse can cause accelerated atherosclerosis and cardiovascular complications possibly resulting from separate mechanisms. These etiologies have not been thoroughly investigated. While regimens containing protease inhibitors (PI) improves survival in patients with HIV, their impact on atherosclerosis still is not fully understood. With longer survival, increasing numbers of HIV infected individuals who also abuse cocaine may face serious threat from cardiovascular complications. The overall goals of this study are (1) to describe prospectively the etiology and natural history of atherosclerosis and the ability of non-invasive tools to measure atherosclerotic burden in black men and women with HIV infection who abuse cocaine, and (2) to investigate whether HIV infection, cocaine abuse and protease inhibitor treatment accelerate atherosclerosis. The proposed study will enroll 160 black men and women with HIV infection and without cardiovascular diseases (40 cocaine (+) and PI(+), 40 cocaine(+) and PI(-), 40 cocaine(-) and PI(+), and 40 cocaine (-) and PI(-)) and 80 black men and women without HIV infection and cardiovascular diseases (40 cocaine (+) and 40 cocaine (-)), and perform baseline interview, clinical examinations, ECG, echocardiographic examinations, lipid profiles and spiral CT for coronary calcium. These study subjects will be re-examined two years later and followed up for at least two years. This study has the potential to provide critical information about the impact of HIV, cocaine abuse and PI on the development of atherosclerosis.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
3R01DA012777-05S1
Application #
6657204
Study Section
Special Emphasis Panel (ZHL1 (F2))
Program Officer
Khalsa, Jagjitsingh H
Project Start
1999-06-15
Project End
2004-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
5
Fiscal Year
2002
Total Cost
$101,779
Indirect Cost
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Lai, Shenghan; Heaphy, Christopher M; Rizzo, Anthony J et al. (2018) Cocaine use may induce telomere shortening in individuals with HIV infection. Prog Neuropsychopharmacol Biol Psychiatry 84:11-17
Li, Ji; Lai, Hong; Chen, Shaoguang et al. (2017) Gender differences in the associations between urinary bisphenol A and body composition among American children: The National Health and Nutrition Examination Survey, 2003-2006. J Epidemiol 27:228-234
Lai, Shenghan; Gerstenblith, Gary; Moore, Richard D et al. (2017) Cocaine use may modify HIV/ART-associated myocardial steatosis and hepatic steatosis. Drug Alcohol Depend 177:84-92
Sandfort, Veit; Bluemke, David A; Vargas, Jose et al. (2017) Coronary Plaque Progression and Regression in Asymptomatic African American Chronic Cocaine Users With Obstructive Coronary Stenoses: A Preliminary Study. J Addict Med 11:126-137
Lai, Hong; Moore, Richard; Celentano, David D et al. (2016) HIV Infection Itself May Not Be Associated With Subclinical Coronary Artery Disease Among African Americans Without Cardiovascular Symptoms. J Am Heart Assoc 5:e002529
Lai, Hong; Stitzer, Maxine; Treisman, Glenn et al. (2015) Cocaine Abstinence and Reduced Use Associated With Lowered Marker of Endothelial Dysfunction in African Americans: A Preliminary Study. J Addict Med 9:331-9
Lai, Shenghan; Gerstenblith, Gary; Li, Ji et al. (2015) Chronic cocaine use and its association with myocardial steatosis evaluated by 1H magnetic resonance spectroscopy in African Americans. J Addict Med 9:31-9
Liu, Chia-Ying; Bluemke, David A; Gerstenblith, Gary et al. (2014) Reference values of myocardial structure, function, and tissue composition by cardiac magnetic resonance in healthy African-Americans at 3T and their relations to serologic and cardiovascular risk factors. Am J Cardiol 114:789-795
Liu, Chia-Ying; Bluemke, David A; Gerstenblith, Gary et al. (2014) Myocardial steatosis and its association with obesity and regional ventricular dysfunction: evaluated by magnetic resonance tagging and 1H spectroscopy in healthy African Americans. Int J Cardiol 172:381-387
Lai, Shenghan; Fishman, Elliot K; Gerstenblith, Gary et al. (2013) Vitamin D deficiency is associated with coronary artery calcification in cardiovascularly asymptomatic African Americans with HIV infection. Vasc Health Risk Manag 9:493-500

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