The long range goal of this work is to understand the encoding and processing of human speech by the brain.
The specific aims of this proposal focus on understanding the role of efferent systems, specifically the olivocochlear system, on stimulus encoding and processing in the awake, behaving cat. Although these efferent systems have been shown to be active in the anesthetized preparations used previously, recent studies in this laboratory on behaving cats have shown enhancements in the neural representation of sounds in awake cats relative to those in anesthetized cats. Rate level functions for best frequency tones for auditory-nerve and cochlear nucleus units are compressed by background noise and their dynamic ranges shifted with respect to those measured in quiet. In awake cats compression is reduced and dynamic range shifts increased for cochlear nucleus units in comparison with those previously measured in anesthetized cats. These changes may improve the ability of the cat to discriminate sounds in noisy environments. The evidence suggests that these differences may be mediated by the olivocochlear bundle (OCB) and the experiments proposed here all explore that suggestion. Rate-level functions for best frequency tones in quite and in noise will be measured in single cochlear nucleus units in awake cats performing a simple discrimination task; within-cat comparisons will be made between three different physiological states: awake with OCB intact and lesioned, and anesthetized. Representations across populations of cochlear nucleus units of vowel spectra and tone frequency in quiet and noise will be measured in cats that are discriminating between two stimuli (two vowels of slightly different formant structure, or two tones of different frequency). The representations in cats with intact and lesioned OCB will be compared with those in anesthetized cats. Quantitative comparisons will be made on the basis of models that use the neural representations to compute predictions of discrimination performance. The results have direct relevance to the design of prostheses for the hearing impaired, including cochlear and CNS prostheses and hearing aids. The are also important to a broad range of aids for the hearing impaired that require computer recognition of speech, such as speech-training aids.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC000109-20
Application #
2124615
Study Section
Hearing Research Study Section (HAR)
Project Start
1975-01-01
Project End
1996-12-31
Budget Start
1994-01-01
Budget End
1994-12-31
Support Year
20
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Biomedical Engineering
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Ropp, Tessa-Jonne F; Tiedemann, Kerrie L; Young, Eric D et al. (2014) Effects of unilateral acoustic trauma on tinnitus-related spontaneous activity in the inferior colliculus. J Assoc Res Otolaryngol 15:1007-22
Paninski, Liam; Ahmadian, Yashar; Ferreira, Daniel Gil et al. (2010) A new look at state-space models for neural data. J Comput Neurosci 29:107-26
May, Bradford J; Little, Nicole; Saylor, Stephanie (2009) Loudness perception in the domestic cat: reaction time estimates of equal loudness contours and recruitment effects. J Assoc Res Otolaryngol 10:295-308
Young, Eric D (2008) Neural representation of spectral and temporal information in speech. Philos Trans R Soc Lond B Biol Sci 363:923-45
Ma, Wei-Li Diana; Young, Eric D (2006) Dorsal cochlear nucleus response properties following acoustic trauma: response maps and spontaneous activity. Hear Res 216-217:176-88
Heinz, Michael G; Issa, John B; Young, Eric D (2005) Auditory-nerve rate responses are inconsistent with common hypotheses for the neural correlates of loudness recruitment. J Assoc Res Otolaryngol 6:91-105
Heinz, Michael G; Young, Eric D (2004) Response growth with sound level in auditory-nerve fibers after noise-induced hearing loss. J Neurophysiol 91:784-95
Ngan, E M; May, B J (2001) Relationship between the auditory brainstem response and auditory nerve thresholds in cats with hearing loss. Hear Res 156:44-52
May, B J; Prell, G S; Sachs, M B (1998) Vowel representations in the ventral cochlear nucleus of the cat: effects of level, background noise, and behavioral state. J Neurophysiol 79:1755-67
Hienz, R D; Stiles, P; May, B J (1998) Effects of bilateral olivocochlear lesions on vowel formant discrimination in cats. Hear Res 116:10-20