Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
3R01DC000156-14A1S1
Application #
2124881
Study Section
Hearing Research Study Section (HAR)
Project Start
1994-07-01
Project End
1998-06-30
Budget Start
1995-02-01
Budget End
1995-06-30
Support Year
14
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Wayne State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Selvakumar, Dakshnamurthy; Drescher, Marian J; Deckard, Nathan A et al. (2017) Dopamine D1A directly interacts with otoferlin synaptic pathway proteins: Ca2+ and phosphorylation underlie an NSF-to-AP2mu1 molecular switch. Biochem J 474:79-104
Drescher, Dennis G; Dakshnamurthy, Selvakumar; Drescher, Marian J et al. (2016) Surface Plasmon Resonance (SPR) Analysis of Binding Interactions of Inner-Ear Proteins. Methods Mol Biol 1427:165-87
Ramakrishnan, Neeliyath A; Drescher, Marian J; Morley, Barbara J et al. (2014) Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis. J Biol Chem 289:8750-66
Selvakumar, Dakshnamurthy; Drescher, Marian J; Drescher, Dennis G (2013) Cyclic nucleotide-gated channel ?-3 (CNGA3) interacts with stereocilia tip-link cadherin 23 + exon 68 or alternatively with myosin VIIa, two proteins required for hair cell mechanotransduction. J Biol Chem 288:7215-29
Ramakrishnan, Neeliyath A; Drescher, Marian J; Drescher, Dennis G (2012) The SNARE complex in neuronal and sensory cells. Mol Cell Neurosci 50:58-69
Ramakrishnan, Neeliyath A; Drescher, Marian J; Khan, Khalid M et al. (2012) HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2. J Biol Chem 287:37628-46
Selvakumar, Dakshnamurthy; Drescher, Marian J; Dowdall, Jayme R et al. (2012) CNGA3 is expressed in inner ear hair cells and binds to an intracellular C-terminus domain of EMILIN1. Biochem J 443:463-76
Drescher, Dennis G; Cho, Won Jin; Drescher, Marian J (2011) Identification of the porosome complex in the hair cell. Cell Biol Int Rep (2010) 18:
Drescher, M J; Cho, W J; Folbe, A J et al. (2010) An adenylyl cyclase signaling pathway predicts direct dopaminergic input to vestibular hair cells. Neuroscience 171:1054-74
Ramakrishnan, Neeliyath A; Drescher, Marian J; Barretto, Roberto L et al. (2009) Calcium-dependent binding of HCN1 channel protein to hair cell stereociliary tip link protein protocadherin 15 CD3. J Biol Chem 284:3227-38

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