Our objectives are (1) to account for aphasic deficits in terms of psycholinguistic theory and (2) to test models of language processing by extending them to the phenomena of language breakdown. Section (1) concerns studies of lexical-phonological retrieval: to amass evidence on individual differences in error patterns in naming and repetition, including changes linked to recovery; to strengthen evidence that nonword errors generated in naming are influenced by lexical factors; to analyze how structural and sequential factors influence nonword errors in naming; and to determine whether movement errors in connected speech occur at above chance rates in individual aphasics. (2) concerns context-sensitive naming disorders.
The aims are to develop reliable diagnostic procedures for these disorders; and to test and extend the theoretical accounts proposed by investigators who reported them. (3 ) presents studies of sentence processing that focus on aphasic deficits and grammatical processing.
Aims i nclude: to evaluate """"""""mapping"""""""" and """"""""working memory"""""""" accounts of agrammatic comprehension; to determine whether the poor performance of Wernicke's aphasics on grammaticality judgment tests reflects deficits at the single word level or grammatical structures; to replicate with new methods the finding that complexity of meaning facilitates verb access in some patients; and to provide data to test a computational account of this phenomenon that relates it to agrammatism. (4) links computational modeling to the empirical work described above: to compare two models of lexical retrieval for their ability to capture naming, repetition, and recovery data; to extend these models to account for neighborhood density effects, context-sensitive naming disorders and other challenging data; to develop a new connectionist learning model that produces multisyllabic words as true sequences and test this model against nonword phonological errors; and to develop a model of grammatical encoding that can be used to understand impaired access to verbs and multiple word sequences.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC000191-21
Application #
6523403
Study Section
Special Emphasis Panel (ZRG1-BBBP-3 (01))
Program Officer
Cooper, Judith
Project Start
1982-04-01
Project End
2003-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
21
Fiscal Year
2002
Total Cost
$537,342
Indirect Cost
Name
Temple University
Department
Neurology
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Mirman, Daniel; Landrigan, Jon-Frederick; Kokolis, Spiro et al. (2018) Corrections for multiple comparisons in voxel-based lesion-symptom mapping. Neuropsychologia 115:112-123
Thye, Melissa; Mirman, Daniel (2018) Relative contributions of lesion location and lesion size to predictions of varied language deficits in post-stroke aphasia. Neuroimage Clin 20:1129-1138
Schuchard, Julia; Middleton, Erica L; Schwartz, Myrna F (2017) The timing of spontaneous detection and repair of naming errors in aphasia. Cortex 93:79-91
Pustina, Dorian; Coslett, Harry Branch; Ungar, Lyle et al. (2017) Enhanced estimations of post-stroke aphasia severity using stacked multimodal predictions. Hum Brain Mapp 38:5603-5615
Pustina, Dorian; Coslett, H Branch; Turkeltaub, Peter E et al. (2016) Automated segmentation of chronic stroke lesions using LINDA: Lesion identification with neighborhood data analysis. Hum Brain Mapp 37:1405-21
Kittredge, Audrey K; Dell, Gary S (2016) Learning to speak by listening: Transfer of phonotactics from perception to production. J Mem Lang 89:8-22
Middleton, Erica L; Schwartz, Myrna F; Rawson, Katherine A et al. (2016) Towards a Theory of Learning for Naming Rehabilitation: Retrieval Practice and Spacing Effects. J Speech Lang Hear Res 59:1111-1122
Schwartz, Myrna F; Middleton, Erica L; Brecher, Adelyn et al. (2016) Does naming accuracy improve through self-monitoring of errors? Neuropsychologia 84:272-81
Mirman, Daniel; Zhang, Yongsheng; Wang, Ze et al. (2015) The ins and outs of meaning: Behavioral and neuroanatomical dissociation of semantically-driven word retrieval and multimodal semantic recognition in aphasia. Neuropsychologia 76:208-19
Mirman, Daniel; Chen, Qi; Zhang, Yongsheng et al. (2015) Neural organization of spoken language revealed by lesion-symptom mapping. Nat Commun 6:6762

Showing the most recent 10 out of 65 publications