The long-term objective of this research is to understand fundamental neural coding mechanisms and neural circuits in auditory cortex that subserve cortical representations of biologically important sounds. We will use the common marmoset (Callithrix jacchus) as our experimental model to investigate these questions. Marmosets have a hearing range similar to that of humans and are an ideal model system for studying audition and deficits and diseases in hearing. With the recent progress in creating transgenic marmosets, this model system is poised to become a major non-human primate model for hearing research. Our laboratory has pioneered major neural recording techniques in awake and behaving marmosets. In this application, we will focus on elucidating neural coding mechanisms underlying spatial and harmonic processing in non-primary auditory cortex.
Aim 1 will characterize functional properties of parabelt areas of auditory cortex.
Aim 2 will study cortical organization of spatial information.
Aim 3 will study topographic organization of harmonic processing in marmoset auditory cortex. Findings from the proposed study will shed lights on neural mechanisms responsible for hearing and have implications for understanding how the auditory system operates in normal or diseased conditions.

Public Health Relevance

Understanding how the brain processes sounds is important to the well being of everyone in the society. Findings of the present study will contribute to our understanding of neural mechanisms underlying hearing in the brain. They will have important implications for understanding human hearing mechanisms in both normal and pathological conditions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC003180-25
Application #
10111501
Study Section
Auditory System Study Section (AUD)
Program Officer
Poremba, Amy
Project Start
1997-01-01
Project End
2025-01-31
Budget Start
2021-02-01
Budget End
2022-01-31
Support Year
25
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Biomedical Engineering
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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