The purpose of this research is to investigate monaural auditory temporal processing new psychophysical data with quantitative model predictions. The project has three main aims: (i) To investigate the influence of peripheral (cochlear) non-linearities on psychophysical measures of temporal resolution; (ii) to examine the consequences of a loss of non-linearity due to sensorineural hearing loss; and (iii) to functionally characterize higher stages of temporal processing. Two experiments will examine the magnitude and the time course of psychophysical suppression to discover the extent of which physiological and psychophysical suppression are reflections of the same underlying process. The results will clarify the role of suppression in certain measures of temporal resolution. Further experiments will test the hypothesis that the non-linear growth of forward masking is a reflection of peripheral non-linearities and that more central processes can be treated as quasi linear. Results from normal-hearing listeners will be compared with those from listeners with moderate-to severe cochlear hearing loss to test whether the differences can be accounted for solely by the expected changes in peripheral compression. The hypothesis, if supported, will have important consequences for the modeling and understanding of temporal resolution in hearing-impaired listeners. The penultimate experiments will seek to elucidate the underlying mechanisms of forward masking comparing predictions of the two most popular theories, namely adaptation of response and persistence (or integration) of response, with experimental data designed to distinguish between the two. The final experiment will examine how information is combined across frequency in a forward-masking situation. An understanding of the changes in temporal resolution due to hearing impairment may ultimately assist in selecting appropriate parameters for the design of digital hearing aids.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC003909-04
Application #
6350562
Study Section
Special Emphasis Panel (ZRG1-IFCN-6 (01))
Program Officer
Donahue, Amy
Project Start
1999-02-01
Project End
2004-01-31
Budget Start
2001-02-01
Budget End
2002-01-31
Support Year
4
Fiscal Year
2001
Total Cost
$148,312
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Internal Medicine/Medicine
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Gregan, Melanie J; Nelson, Peggy B; Oxenham, Andrew J (2013) Behavioral measures of cochlear compression and temporal resolution as predictors of speech masking release in hearing-impaired listeners. J Acoust Soc Am 134:2895-912
Gregan, Melanie J; Nelson, Peggy B; J Oxenham, Andrew (2011) Behavioral estimates of basilar-membrane compression: additivity of forward masking in noise-masked normal-hearing listeners. J Acoust Soc Am 130:2835-44
Wojtczak, Magdalena; Oxenham, Andrew J (2010) Recovery from on- and off-frequency forward masking in listeners with normal and impaired hearing. J Acoust Soc Am 128:247-56
Shera, Christopher A; Guinan Jr, John J; Oxenham, Andrew J (2010) Otoacoustic estimation of cochlear tuning: validation in the chinchilla. J Assoc Res Otolaryngol 11:343-65
Dau, Torsten; Ewert, Stephan; Oxenham, Andrew J (2009) Auditory stream formation affects comodulation masking release retroactively. J Acoust Soc Am 125:2182-8
Wojtczak, Magdalena; Oxenham, Andrew J (2009) On- and off-frequency forward masking by Schroeder-phase complexes. J Assoc Res Otolaryngol 10:595-607
Wojtczak, Magdalena; Oxenham, Andrew J (2009) Pitfalls in behavioral estimates of basilar-membrane compression in humans. J Acoust Soc Am 125:270-81
Gutschalk, Alexander; Micheyl, Christophe; Oxenham, Andrew J (2008) The pulse-train auditory aftereffect and the perception of rapid amplitude modulations. J Acoust Soc Am 123:935-45
Dreyer, Anna A; Oxenham, Andrew J (2008) Effects of level and background noise on interaural time difference discrimination for transposed stimuli. J Acoust Soc Am 123:EL1-7
Plack, Christopher J; Oxenham, Andrew J; Simonson, Andrea M et al. (2008) Estimates of compression at low and high frequencies using masking additivity in normal and impaired ears. J Acoust Soc Am 123:4321-30

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