Advances in combined orthodontic and surgical treatment have made it possible to correct or significantly improve dentofacial deformities which could not be treated previously, with significant progress continuing to occur at a rapid rate. Although the long-term results of orthognathic surgery are stable in most instances, there are some post-treatment changes in morphology in almost all patients and significant relapse in a few. The alterations in jaw position and oral cavity volume produced by this surgery require considerable physiologic adaptation, and it is likely that the extent of post-treatment morphologic change is related to the extent and pattern of physiologic adaptation. In this project, patients undergoing surgical-orthodontic treatment through the UNC Dentofacial Program will be studied. Morphologic stability will be evaluated and correlations will be sought between post-treatment morphologic changes and (1) posture of the head, mandible and tongue as evaluated from natural head position cephalometric radiographs, (2) lip pressures and function, measured with miniature intra-oral pressure transducers, (3) the balance of tongue and lip forces across the lower dental arch, (4) respiratory mode, as evaluated using the newly-developed SNORT apparatus for measurement of nasal/oral airflow ratios, (5) vertically directed tongue pressures, and (6) occlusal forces during swallowing, chewing and maximum effort, as evaluated using piezo-electric force transducers. The data base will be used to test a series of specific hypotheses related to clinically important questions. The project should provide insight into soft tissue function as a factor in the etiology of dentofacial deformity as well as a determinant of post-treatment stability.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE005215-07
Application #
3219288
Study Section
Oral Biology and Medicine Study Section (OBM)
Project Start
1979-01-01
Project End
1987-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
Schools of Dentistry/Oral Hygn
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Brookes, Carolyn Dicus; Berry, John; Rich, Josiah et al. (2015) Multimodal protocol reduces postoperative nausea and vomiting in patients undergoing Le Fort I osteotomy. J Oral Maxillofac Surg 73:324-32
Brookes, Carolyn Dicus; Turvey, Timothy A; Phillips, Ceib et al. (2015) Postdischarge Nausea and Vomiting Remains Frequent After Le Fort I Osteotomy Despite Implementation of a Multimodal Antiemetic Protocol Effective in Reducing Postoperative Nausea and Vomiting. J Oral Maxillofac Surg 73:1259-66
Phillips, C; Brookes, C D; Rich, J et al. (2015) Postoperative nausea and vomiting following orthognathic surgery. Int J Oral Maxillofac Surg 44:745-51
Brookes, Carolyn Dicus; Golden, Brent A; Lawrence, Scott D et al. (2015) Unilateral mydriasis after maxillary osteotomy: a case series and review of the literature. J Oral Maxillofac Surg 73:1159-68
Magraw, Caitlin B L; Garaas, Rachel; Shaw, Alan et al. (2015) Changes in scleral exposure following modified Le Fort III osteotomy. Oral Surg Oral Med Oral Pathol Oral Radiol 120:119-24.e1
Nguyen, Tung; Cevidanes, Lucia; Paniagua, Beatriz et al. (2014) Use of shape correspondence analysis to quantify skeletal changes associated with bone-anchored Class III correction. Angle Orthod 84:329-36
Perin, J; Preisser, J S; Phillips, C et al. (2014) Regression analysis of correlated ordinal data using orthogonalized residuals. Biometrics 70:902-9
Blakey, G H; Rossouw, E; Turvey, T A et al. (2014) Are bioresorbable polylactate devices comparable to titanium devices for stabilizing Le Fort I advancement? Int J Oral Maxillofac Surg 43:437-44
Rich, J; Golden, B A; Phillips, C (2014) Systematic review of preoperative mandibular canal position as it relates to postoperative neurosensory disturbance following the sagittal split ramus osteotomy. Int J Oral Maxillofac Surg 43:1076-81
Scheffler, Nicole R; Proffit, William R; Phillips, Ceib (2014) Outcomes and stability in patients with anterior open bite and long anterior face height treated with temporary anchorage devices and a maxillary intrusion splint. Am J Orthod Dentofacial Orthop 146:594-602

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