Several recent studies have reported an increase in the prevalence of dental fluorosis in the United States, thought to be due to the widespread adoption of various preventive dentistry initiatives using fluoride. Several retrospective studies have found associations between dental fluorosis and these fluoride exposures, especially water fluoridation and fluoride tablets and drops. In this study, a methodology will be developed and implemented for use in longitudinal studies to record dietary and non-dietary fluoride exposures on a 3 month basis in a 'birth cohort' from the time of birth until the age of 3 to 4 years (and in a subsequent study until age 8 years). 1530 mothers with newborns will be recruited from post-partum wards of hospitals. The parents will provide data on infant and childhood exposures and ingestion of fluoride every 3 months during the study, with an additional report at 6 weeks of age (due to frequent feeding habit changes during the first 3 months of life). Data on fluoride intake have not previously been collected in this manner and will be valuable in characterizing the multiple fluoride exposures among infants and young children in the U.S. Composite indexes of exposures to both individual and various combinations of fluoride sources over time will be developed. Total dietary fluoride intake will be estimated. Dental caries and dental fluorosis of the primary teeth will be assessed at age 3 to 4. The distributions of fluoride exposures and intake will be characterized. Multivariate relationships will be investigated among prevalence and severity of primary tooth dental fluorosis and dental caries and the various fluoride exposures. A subsequent study will follow the cohort to age 7 to 8 allowing longitudinal data on fluoride exposures to be collected from birth to age 7 to 8. Then, relationships between primary and permanent tooth dental fluorosis will be assessed and the strength of the associations between the prevalence and severity of permanent tooth dental fluorosis and the """"""""prospectively-collected"""""""" data on fluoride exposures would be assessed. The study results will increase current understanding about the delicate balance between the optimal use of fluorides for caries prevention and increased risks of dental fluorosis so that fluoride can continue to be used appropriately for maximum public health caries prevention with minimal risk of dental fluorosis.
| Glass, Natalie A; Torner, James C; Letuchy, Elena M et al. (2018) Does Visceral or Subcutaneous Fat Influence Peripheral Cortical Bone Strength During Adolescence? A Longitudinal Study. J Bone Miner Res 33:580-588 |
| Curtis, Alexandra M; VanBuren, John; Cavanaugh, Joseph E et al. (2018) Longitudinal associations between dental caries increment and risk factors in late childhood and adolescence. J Public Health Dent 78:321-328 |
| Ballantine, Jami L; Carlson, Jenna C; Ferreira Zandoná, Andrea G et al. (2018) Exploring the genomic basis of early childhood caries: a pilot study. Int J Paediatr Dent 28:217-225 |
| Lorenz, Douglas J; Levy, Steven; Datta, Somnath (2018) Inferring marginal association with paired and unpaired clustered data. Stat Methods Med Res 27:1806-1817 |
| Oweis, Reem Reda; Levy, Steven M; Eichenberger-Gilmore, Julie M et al. (2018) Fluoride intake and cortical and trabecular bone characteristics in adolescents at age 17: A prospective cohort study. Community Dent Oral Epidemiol 46:527-534 |
| Curtis, A M; Cavanaugh, J E; Levy, S M et al. (2018) Examining caries aetiology in adolescence with structural equation modelling. Community Dent Oral Epidemiol 46:258-264 |
| Choo-Wosoba, Hyoyoung; Gaskins, Jeremy; Levy, Steven et al. (2018) A Bayesian approach for analyzing zero-inflated clustered count data with dispersion. Stat Med 37:801-812 |
| Haworth, Simon; Shungin, Dmitry; van der Tas, Justin T et al. (2018) Consortium-based genome-wide meta-analysis for childhood dental caries traits. Hum Mol Genet 27:3113-3127 |
| Govil, Manika; Mukhopadhyay, Nandita; Weeks, Daniel E et al. (2018) Novel caries loci in children and adults implicated by genome-wide analysis of families. BMC Oral Health 18:98 |
| Levy, Steven M; Eichenberger-Gilmore, Julie M; Warren, John J et al. (2018) Associations of fluoride intake with children's cortical bone mineral and strength measures at age 11. J Public Health Dent 78:352-359 |
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