Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK013332-28
Application #
2136774
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1977-01-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
28
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Garai, Kanchan; Baban, Berevan; Frieden, Carl (2011) Dissociation of apolipoprotein E oligomers to monomer is required for high-affinity binding to phospholipid vesicles. Biochemistry 50:2550-8
Garai, Kanchan; Mustafi, Sourajit M; Baban, Berevan et al. (2010) Structural differences between apolipoprotein E3 and E4 as measured by (19)F NMR. Protein Sci 19:66-74
Baldwin, Robert L; Frieden, Carl; Rose, George D (2010) Dry molten globule intermediates and the mechanism of protein unfolding. Proteins 78:2725-37
Garai, Kanchan; Frieden, Carl (2010) The association?dissociation behavior of the ApoE proteins: kinetic and equilibrium studies. Biochemistry 49:9533-41
Mustafi, Sourajit M; Garai, Kanchan; Crick, Scott L et al. (2010) Substoichiometric inhibition of Abeta(1-40) aggregation by a tandem Abeta(40-1-Gly8-1-40) peptide. Biochem Biophys Res Commun 397:509-12
Niu, Weiling; Shu, Qin; Chen, Zhiwei et al. (2010) The role of Zn2+ on the structure and stability of murine adenosine deaminase. J Phys Chem B 114:16156-65
Hu, Xiaoyan; Crick, Scott L; Bu, Guojun et al. (2009) Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. Proc Natl Acad Sci U S A 106:20324-9
Garai, Kanchan; Crick, Scott L; Mustafi, Sourajit M et al. (2009) Expression and purification of amyloid-beta peptides from Escherichia coli. Protein Expr Purif 66:107-12
Zhang, Rui; Hu, Xiaoyan; Khant, Htet et al. (2009) Interprotofilament interactions between Alzheimer's Abeta1-42 peptides in amyloid fibrils revealed by cryoEM. Proc Natl Acad Sci U S A 106:4653-8
Frieden, Carl (2007) Protein aggregation processes: In search of the mechanism. Protein Sci 16:2334-44

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