We will study methods to prevent the end stage renal disease which may follow rer infection. This will include prevention of the disease as well as modulation of the cute host response to the bacteria since this response can cause renal damage. The organisms to be tested include Escherichia coli, Proteus mirabilis, Staphylococcus saprophyticus and Klebsiella. Our attempt to prevent-the disease involves vaccination with both artificial or K-antigen specific oligosaccharide-protein conjugates to produce protective antibodies, as well as production of anti- idiotype antibodies which will be protective against disease. To determine the best method to prevent or modulate the renal damage which occurs during infection we will study the acute phase reactants. These include complement, interleukins, the eicosinoids, and leukocytes to include granulocytes and the subset of lymphocytes. As part of our attempt to understand as well as prevent the renal damage, we will modulate it by treatment with antibiotics, corticosteroids, anti-inflammatory agents, calcium channel blockers and immunization.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK014681-22
Application #
3225267
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1978-09-01
Project End
1993-08-31
Budget Start
1991-09-01
Budget End
1992-08-31
Support Year
22
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Tulane University
Department
Type
Schools of Medicine
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Roberts, J A; Kaack, M B (2000) Grantsmanship. J Urol 163:1544-8
Roberts, J A (1999) Management of pyelonephritis and upper urinary tract infections. Urol Clin North Am 26:753-63
Roberts, J A (1999) Pathophysiology of bacterial cystitis. Adv Exp Med Biol 462:325-38
Roberts, J A; Kaack, M B; Harrison, R M et al. (1999) Bladder infection in the menopausal monkey. J Urol 162:254-7
Roberts, J A; Kaack, M B; Baskin, G et al. (1997) Epitopes of the P-fimbrial adhesin of E. coli cause different urinary tract infections. J Urol 158:1610-3
Roberts, J A (1996) Factors predisposing to urinary tract infections in children. Pediatr Nephrol 10:517-22
Roberts, J A (1996) Tropism in bacterial infections: urinary tract infections. J Urol 156:1552-9
Roberts, J A (1995) Mechanisms of renal damage in chronic pyelonephritis (reflux nephropathy). Curr Top Pathol 88:265-87
Monga, M; Roberts, J A (1995) The possible role of granulocyte elastase in renal damage from acute pyelonephritis. Pediatr Nephrol 9:583-6
Roberts, J A; Marklund, B I; Ilver, D et al. (1994) The Gal(alpha 1-4)Gal-specific tip adhesin of Escherichia coli P-fimbriae is needed for pyelonephritis to occur in the normal urinary tract. Proc Natl Acad Sci U S A 91:11889-93

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