Regulation of Protein Synthesis and Erythropoiesis

Chen, Jane-Jane

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK016272-22
• Application #: 2136998
• Study Section: Hematology Subcommittee 2 (HEM)
• Project Start: 1979-01-01
• Project End: 1997-03-31
• Budget Start: 1994-07-01
• Budget End: 1997-03-31
• Support Year: 22
• Fiscal Year: 1994

Institution

• Name: Massachusetts Institute of Technology
• Type: Organized Research Units
• City: Cambridge
• State: MA
• Country: United States
• Zip Code: 02139

Publications

Suragani, Rajasekhar N V S; Zachariah, Roshini S; Velazquez, Jason G et al. (2012) Heme-regulated eIF2? kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis. Blood 119:5276-84

Acharya, Poulomi; Chen, Jane-Jane; Correia, Maria Almira (2010) Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone. Mol Pharmacol 77:575-92

Liu, Sijin; Suragani, Rajasekhar N V S; Wang, Fudi et al. (2007) The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. J Clin Invest 117:3296-305

Chen, Jane-Jane (2007) Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias. Blood 109:2693-9

McEwen, Edward; Kedersha, Nancy; Song, Benbo et al. (2005) Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure. J Biol Chem 280:16925-33

Han, An-Ping; Fleming, Mark D; Chen, Jane-Jane (2005) Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia. J Clin Invest 115:1562-70

Lu, Linrong; Chen, Jane Jane (2002) Molecular cloning and characterization of the promoter of mouse heme-regulated eIF2alpha kinase. Biochim Biophys Acta 1574:193-9

Bauer, B N; Rafie-Kolpin, M; Lu, L et al. (2001) Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase. Biochemistry 40:11543-51

Kumar, R; Azam, S; Sullivan, J M et al. (2001) Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK. J Neurochem 77:1418-21

Rosenwald, I B; Pechet, L; Han, A et al. (2001) Expression of translation initiation factors elF-4E and elF-2alpha and a potential physiologic role of continuous protein synthesis in human platelets. Thromb Haemost 85:142-51