Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK019514-17A1
Application #
2137336
Study Section
Metabolism Study Section (MET)
Project Start
1979-06-01
Project End
2000-03-31
Budget Start
1996-04-04
Budget End
1997-03-31
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118
Mugabo, Yves; Zhao, Shangang; Seifried, Annegrit et al. (2016) Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic ?-cells and hepatocytes. Proc Natl Acad Sci U S A 113:E430-9
Weikel, Karen A; Cacicedo, José M; Ruderman, Neil B et al. (2016) Knockdown of GSK3? increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep 36:
Coughlan, Kimberly A; Valentine, Rudy J; Sudit, Bella S et al. (2016) PKD1 Inhibits AMPK?2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem 291:5664-75
Weikel, Karen A; Ruderman, Neil B; Cacicedo, José M (2016) Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights. Metabolism 65:634-45
Pepin, Émilie; Al-Mass, Anfal; Attané, Camille et al. (2016) Pancreatic ?-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase C?, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression. PLoS One 11:e0153017
Xu, X Julia; Apovian, Caroline; Hess, Donald et al. (2015) Improved Insulin Sensitivity 3 Months After RYGB Surgery Is Associated With Increased Subcutaneous Adipose Tissue AMPK Activity and Decreased Oxidative Stress. Diabetes 64:3155-9
Nolan, Christopher J; Ruderman, Neil B; Kahn, Steven E et al. (2015) Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetes. Diabetes 64:673-86
Coughlan, Kimberly A; Balon, Thomas W; Valentine, Rudy J et al. (2015) Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats. PLoS One 10:e0127388
Doménech, Elena; Maestre, Carolina; Esteban-Martínez, Lorena et al. (2015) AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nat Cell Biol 17:1304-16
Martínez de Morentin, Pablo B; Lage, Ricardo; González-García, Ismael et al. (2015) Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-CoA and the thermogenic effect of hypothalamic AMPK inhibition in female rats. Endocrinology 156:947-60

Showing the most recent 10 out of 92 publications