Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK020251-20
Application #
2137438
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1977-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost
Name
North Carolina State University Raleigh
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
City
Raleigh
State
NC
Country
United States
Zip Code
27695
Behera, Rabindra K; Torres, Rodrigo; Tosha, Takehiko et al. (2015) Fe(2+) substrate transport through ferritin protein cage ion channels influences enzyme activity and biomineralization. J Biol Inorg Chem 20:957-69
Pozzi, Cecilia; Di Pisa, Flavio; Lalli, Daniela et al. (2015) Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites. Acta Crystallogr D Biol Crystallogr 71:941-53
Theil, Elizabeth C; Turano, Paola; Ghini, Veronica et al. (2014) Coordinating subdomains of ferritin protein cages with catalysis and biomineralization viewed from the C4 cage axes. J Biol Inorg Chem 19:615-22
Khan, Mateen A; Ma, Jia; Walden, William E et al. (2014) Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions. Nucleic Acids Res 42:6567-77
Behera, Rabindra K; Theil, Elizabeth C (2014) Moving Fe2+ from ferritin ion channels to catalytic OH centers depends on conserved protein cage carboxylates. Proc Natl Acad Sci U S A 111:7925-30
Kwak, Yeonju; Schwartz, Jennifer K; Haldar, Suranjana et al. (2014) Spectroscopic studies of single and double variants of M ferritin: lack of conversion of a biferrous substrate site into a cofactor site for O2 activation. Biochemistry 53:473-82
Theil, Elizabeth C; Turano, Paola (2013) Metalloenzymes: Cage redesign explains assembly. Nat Chem Biol 9:143-4
Dehner, Carolyn; Morales-Soto, Nydia; Behera, Rabindra K et al. (2013) Ferritin and ferrihydrite nanoparticles as iron sources for Pseudomonas aeruginosa. J Biol Inorg Chem 18:371-81
Theil, Elizabeth C (2013) Ferritin: the protein nanocage and iron biomineral in health and in disease. Inorg Chem 52:12223-33
Tosha, Takehiko; Behera, Rabindra K; Theil, Elizabeth C (2012) Ferritin ion channel disorder inhibits Fe(II)/O2 reactivity at distant sites. Inorg Chem 51:11406-11

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