The proposed research will evaluate the immunologic and environmental determinants of the risk of insulin dependent diabetes mellitus (IDDM). Specifically, we will: 1. Monitor the incidence of IDDM in Allegheny County, PA, over 25 years (1965-1990) as well as the world. 2. Assess the associations between specific serologic and molecular markers to the risk of IDDM in 90 multiple sibling families, 58 affected parent offspring families, and 60 single case families. 3. Evaluate the association between viral DNA insertion into the human genome and IDDM. 4. Continue to collect samples on first degree relatives of cases prior to conversion to IDDM.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK024021-13
Application #
3227252
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1978-09-15
Project End
1993-11-30
Budget Start
1991-02-01
Budget End
1991-11-30
Support Year
13
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Children's Hosp Pittsburgh/Upmc Health Sys
Department
Type
DUNS #
044304145
City
Pittsburgh
State
PA
Country
United States
Zip Code
15224
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