Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK025541-19
Application #
2137751
Study Section
Biochemistry Study Section (BIO)
Project Start
1978-08-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Yang, Jianqi; Kong, Xiaoying; Martins-Santos, Maria Emilia S et al. (2009) Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha. J Biol Chem 284:27042-53
Yang, Jianqi; Reshef, Lea; Cassuto, Hanoch et al. (2009) Aspects of the control of phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem 284:27031-5
Nye, Colleen K; Hanson, Richard W; Kalhan, Satish C (2008) Glyceroneogenesis is the dominant pathway for triglyceride glycerol synthesis in vivo in the rat. J Biol Chem 283:27565-74
Montano, Monica M; Doughman, Yong Qui; Deng, Huayun et al. (2008) Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor. Circ Res 102:415-22
Liu, George E; Weirauch, Matthew T; Van Tassell, Curtis P et al. (2008) Identification of conserved regulatory elements in mammalian promoter regions: a case study using the PCK1 promoter. Genomics Proteomics Bioinformatics 6:129-43
Hanson, Richard W; Hakimi, Parvin (2008) Born to run;the story of the PEPCK-Cmus mouse. Biochimie 90:838-42
Chalhoub, Elie; Hanson, Richard W; Belovich, Joanne M (2007) A computer model of gluconeogenesis and lipid metabolism in the perfused liver. Am J Physiol Endocrinol Metab 293:E1676-86
Chakravarty, Kaushik; Hanson, Richard W (2007) Insulin regulation of phosphoenolpyruvate carboxykinase-c gene transcription: the role of sterol regulatory element-binding protein 1c. Nutr Rev 65:S47-56
Hakimi, Parvin; Yang, Jianqi; Casadesus, Gemma et al. (2007) Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J Biol Chem 282:32844-55
Xu, Chuan; Chakravarty, Kaushik; Kong, Xiaoying et al. (2007) Several transcription factors are recruited to the glucose-6-phosphatase gene promoter in response to palmitate in rat hepatocytes and H4IIE cells. J Nutr 137:554-9

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