Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK026214-18
Application #
2137835
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1979-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Colorado State University-Fort Collins
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
112617480
City
Fort Collins
State
CO
Country
United States
Zip Code
80523
Doll, Kenneth M; Bender, Bruce R; Finke, Richard G (2003) The first experimental test of the hypothesis that enzymes have evolved to enhance hydrogen tunneling. J Am Chem Soc 125:10877-84
Doll, Kenneth M; Finke, Richard G (2003) A compelling experimental test of the hypothesis that enzymes have evolved to enhance quantum mechanical tunneling in hydrogen transfer reactions: the beta-neopentylcobalamin system combined with prior adocobalamin data. Inorg Chem 42:4849-56
Doll, Kenneth M; Fleming, Paul E; Finke, Richard G (2002) The synthesis and characterization of 8-methoxy-5'-deoxyadenosylcobalamin: a coenzyme B(12) analog which, following Co-C bond homolysis, avoids cyclization of the 8-methoxy-5'-deoxyadenosyl radical. J Inorg Biochem 91:388-97
White, Wesley T; Finke, Richard G (2002) Synthesis of adenosylcobinamide 2-chlorophenyl phosphate, a zwitterionic cobinamide phosphate analog of adenosylcobalamin en route to crystallizable cobinamides. J Inorg Biochem 91:371-87
Suto, R K; Brasch, N E; Anderson, O P et al. (2001) Synthesis, characterization, solution stability, and X-ray crystal structure of the thiolatocobalamin gamma-glutamylcysteinylcobalamin, a dipeptide analogue of glutathionylcobalamin: insights into the enhanced Co-S bond stability of the natural product gl Inorg Chem 40:2686-92
Brasch, N E; Hsu, T L; Doll, K M et al. (1999) Synthesis and characterization of isolable thiolatocobalamin complexes relevant to coenzyme B12-dependent ribonucleoside triphosphate reductase. J Inorg Biochem 76:197-209
Suto, R K; Whalen, M A; Finke, R G (1999) Adenosylcobalamin-dependent ribonucleoside triphosphate reductase from Lactobacillus leichmannii. Rapid, improved purification involving dGTP-based affinity chromatography plus biophysical characterization studies demonstrating enhanced, ""crystallographi Prep Biochem Biotechnol 29:273-309
Brasch, N E; Finke, R G (1999) A simple, convenient and direct method for assessing the purity of cobalamins. J Inorg Biochem 73:215-9
Suto, R K; Whalen, M A; Bender, B R et al. (1998) Synthesis of gamma-phosphate-linked nucleoside affinity chromatography resins for protein purification, including ribonucleoside triphosphate reductase. Nucleosides Nucleotides 17:1453-71
Finke, R G; Martin, B D (1990) Coenzyme AdoB12 vs AdoB12.-homolytic Co-C cleavage following electron transfer: a rate enhancement greater than or equal to 10(12). J Inorg Biochem 40:19-22