Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK027726-13
Application #
2138049
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1980-12-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Ohgami, Robert S; Campagna, Dean R; Antiochos, Brendan et al. (2005) nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. Blood 106:3625-31
Vogler, Carole; Levy, Beth; Galvin, Nancy et al. (2005) Early onset of lysosomal storage disease in a murine model of mucopolysaccharidosis type VII: undegraded substrate accumulates in many tissues in the fetus and very young MPS VII mouse. Pediatr Dev Pathol 8:453-62
Barker, Jane E; Deveau, Susan A; Compton, Sheila T et al. (2005) High incidence, early onset of histiocytic sarcomas in mice with Hertwig's anemia. Exp Hematol 33:1118-29
Soper, Brian W; Duffy, Ted M; Lessard, Mark D et al. (2004) Transplanted ER-MP12hi20-58med/hi myeloid progenitors produce resident macrophages from marrow that are therapeutic for lysosomal storage disease. Blood Cells Mol Dis 32:199-213
Schuldt, A J T; Hampton, T J; Chu, V et al. (2004) Electrocardiographic and other cardiac anomalies in beta-glucuronidase-null mice corrected by nonablative neonatal marrow transplantation. Proc Natl Acad Sci U S A 101:603-8
Barker, Jane E; Schuldt, Adam J T; Lessard, Mark L et al. (2003) Donor cell expansion is delayed following nonablative in utero transplantation to treat murine mucopolysaccharidosis type VII. Exp Hematol 31:1112-8
Barker, J E; Schuldt, A J T; Lessard, M D et al. (2003) Donor cell replacement in mice transplanted in utero is limited by immune-independent mechanisms. Blood Cells Mol Dis 31:291-7
Soper, Brian W; Lessard, Mark D; Jude, Craig D et al. (2002) Delayed administration of carrier marrow can decrease competition on donor stem cells during engraftment and maintain radioprotection of the host. Exp Hematol 30:837-45
Soper, B W; Lessard, M D; Vogler, C A et al. (2001) Nonablative neonatal marrow transplantation attenuates functional and physical defects of beta-glucuronidase deficiency. Blood 97:1498-504
Donsante, A; Vogler, C; Muzyczka, N et al. (2001) Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors. Gene Ther 8:1343-6

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