Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK028312-17
Application #
2016052
Study Section
Metabolism Study Section (MET)
Project Start
1981-04-01
Project End
2001-03-31
Budget Start
1996-09-17
Budget End
1997-03-31
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Pharmacology
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Zhang, Chongben; Wendel, Angela A; Keogh, Matthew R et al. (2012) Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling. Proc Natl Acad Sci U S A 109:1667-72
Péterfy, Miklós; Harris, Thurl E; Fujita, Naoya et al. (2010) Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes. J Biol Chem 285:3857-64
Liu, Guang-Hui; Qu, Jing; Carmack, Anne E et al. (2010) Lipin proteins form homo- and hetero-oligomers. Biochem J 432:65-76
Blancquaert, Sara; Wang, Lifu; Paternot, Sabine et al. (2010) cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4. Mol Endocrinol 24:1453-68
Kim, Hyun Bae; Kumar, Anil; Wang, Lifu et al. (2010) Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol Cell Biol 30:3126-39
Kumar, Anil; Lawrence Jr, John C; Jung, Dae Young et al. (2010) Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes 59:1397-406
Gropler, Matthew C; Harris, Thurl E; Hall, Angela M et al. (2009) Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice. J Biol Chem 284:6763-72
Wang, Lifu; Lawrence Jr, John C; Sturgill, Thomas W et al. (2009) Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR. J Biol Chem 284:14693-7
Chen, Zhouji; Gropler, Matthew C; Norris, Jin et al. (2008) Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion. Arterioscler Thromb Vasc Biol 28:1738-44
Wang, Lifu; Harris, Thurl E; Lawrence Jr, John C (2008) Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation. J Biol Chem 283:15619-27

Showing the most recent 10 out of 72 publications