Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK028348-13
Application #
2138141
Study Section
Endocrinology Study Section (END)
Project Start
1981-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Pediatrics
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Ansari, Israr-Ul H; Longacre, Melissa J; Stoker, Scott W et al. (2017) Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion. Arch Biochem Biophys 618:32-43
El Azzouny, Mahmoud; Longacre, Melissa J; Ansari, Israr-Ul H et al. (2016) Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion. Mol Metab 5:980-987
Ansari, Israr-ul H; Longacre, Melissa J; Paulusma, Coen C et al. (2015) Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION. J Biol Chem 290:23110-23
MacDonald, Michael J; Ade, Lacmbouh; Ntambi, James M et al. (2015) Characterization of phospholipids in insulin secretory granules and mitochondria in pancreatic beta cells and their changes with glucose stimulation. J Biol Chem 290:11075-92
Hasan, Noaman M; Longacre, Melissa J; Stoker, Scott W et al. (2015) Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic ?-cells. Mol Endocrinol 29:396-410
Wutthisathapornchai, Apilak; Vongpipatana, Tuangtong; Muangsawat, Sureeporn et al. (2014) Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element. PLoS One 9:e102730
Madiraju, Anila K; Erion, Derek M; Rahimi, Yasmeen et al. (2014) Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 510:542-6
MacDonald, Michael J; Hasan, Noaman M; Dobrzyn, Agnieszka et al. (2013) Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells. Arch Biochem Biophys 532:23-31
Thonpho, Ansaya; Rojvirat, Pinnara; Jitrapakdee, Sarawut et al. (2013) Characterization of the distal promoter of the human pyruvate carboxylase gene in pancreatic beta cells. PLoS One 8:e55139
MacDonald, M J; Langberg, E-C; Tibell, A et al. (2013) Identification of ATP synthase as a lipid peroxide protein adduct in pancreatic islets from humans with and without type 2 diabetes mellitus. J Clin Endocrinol Metab 98:E727-31

Showing the most recent 10 out of 23 publications