Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK028559-16
Application #
2016057
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1980-09-01
Project End
1999-08-31
Budget Start
1996-09-30
Budget End
1997-08-31
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Salisbury, Travis B; Binder, April K; Grammer, Jean C et al. (2007) Maximal activity of the luteinizing hormone beta-subunit gene requires beta-catenin. Mol Endocrinol 21:963-71
Jorgensen, Joan S; Quirk, Christine C; Nilson, John H (2004) Multiple and overlapping combinatorial codes orchestrate hormonal responsiveness and dictate cell-specific expression of the genes encoding luteinizing hormone. Endocr Rev 25:521-42
Quirk, Christine C; Seachrist, Darcie D; Nilson, John H (2003) Embryonic expression of the luteinizing hormone beta gene appears to be coupled to the transient appearance of p8, a high mobility group-related transcription factor. J Biol Chem 278:1680-5
Mohammad, Helai P; Abbud, Rula A; Parlow, Al F et al. (2003) Targeted overexpression of luteinizing hormone causes ovary-dependent functional adenomas restricted to cells of the Pit-1 lineage. Endocrinology 144:4626-36
Jorgensen, J S; Nilson, J H (2001) AR suppresses transcription of the LHbeta subunit by interacting with steroidogenic factor-1. Mol Endocrinol 15:1505-16
Jorgensen, J S; Nilson, J H (2001) AR suppresses transcription of the alpha glycoprotein hormone subunit gene through protein-protein interactions with cJun and activation transcription factor 2. Mol Endocrinol 15:1496-504
Quirk, C C; Lozada, K L; Keri, R A et al. (2001) A single Pitx1 binding site is essential for activity of the LHbeta promoter in transgenic mice. Mol Endocrinol 15:734-46
Keri, R A; Bachmann, D J; Behrooz, A et al. (2000) An NF-Y binding site is important for basal, but not gonadotropin-releasing hormone-stimulated, expression of the luteinizing hormone beta subunit gene. J Biol Chem 275:13082-8
Abbud, R A; Ameduri, R K; Rao, J S et al. (1999) Chronic hypersecretion of luteinizing hormone in transgenic mice selectively alters responsiveness of the alpha-subunit gene to gonadotropin-releasing hormone and estrogens. Mol Endocrinol 13:1449-59
Budworth, P R; Quinn, P G; Nilson, J H (1997) Multiple characteristics of a pentameric regulatory array endow the human alpha-subunit glycoprotein hormone promoter with trophoblast specificity and maximal activity. Mol Endocrinol 11:1669-80

Showing the most recent 10 out of 24 publications