Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK032822-03
Application #
3231172
Study Section
Biochemistry Study Section (BIO)
Project Start
1984-01-01
Project End
1986-12-31
Budget Start
1986-01-01
Budget End
1986-12-31
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Buchbinder, J L; Rath, V L; Fletterick, R J (2001) Structural relationships among regulated and unregulated phosphorylases. Annu Rev Biophys Biomol Struct 30:191-209
Butte, M J; Hwang, P K; Mobley, W C et al. (1998) Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. Biochemistry 37:16846-52
Buchbinder, J L; Luong, C B; Browner, M F et al. (1997) Partial activation of muscle phosphorylase by replacement of serine 14 with acidic residues at the site of regulatory phosphorylation. Biochemistry 36:8039-44
Rath, V L; Lin, K; Hwang, P K et al. (1996) The evolution of an allosteric site in phosphorylase. Structure 4:463-73
Lin, K; Rath, V L; Dai, S C et al. (1996) A protein phosphorylation switch at the conserved allosteric site in GP. Science 273:1539-42
Buchbinder, J L; Fletterick, R J (1996) Role of the active site gate of glycogen phosphorylase in allosteric inhibition and substrate binding. J Biol Chem 271:22305-9
Crerar, M M; Karlsson, O; Fletterick, R J et al. (1995) Chimeric muscle and brain glycogen phosphorylases define protein domains governing isozyme-specific responses to allosteric activation. J Biol Chem 270:13748-56
Lin, K; Hwang, P K; Fletterick, R J (1995) Mechanism of regulation in yeast glycogen phosphorylase. J Biol Chem 270:26833-9
Buchbinder, J L; Guinovart, J J; Fletterick, R J (1995) Mutations in paired alpha-helices at the subunit interface of glycogen phosphorylase alter homotropic and heterotropic cooperativity. Biochemistry 34:6423-32
Rath, V L; Fletterick, R J (1994) Parallel evolution in two homologues of phosphorylase. Nat Struct Biol 1:681-90

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