Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK033491-12
Application #
2139081
Study Section
Special Emphasis Panel (ZRG2-NTN (03))
Project Start
1984-12-01
Project End
2000-07-31
Budget Start
1996-08-15
Budget End
1997-07-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Sellers, Zachary M; Mann, Elizabeth; Smith, Anders et al. (2008) Heat-stable enterotoxin of Escherichia coli (STa) can stimulate duodenal HCO3(-) secretion via a novel GC-C- and CFTR-independent pathway. FASEB J 22:1306-16
Zhang, Shen; Dong, Hui; Rubin, Lewis J et al. (2007) Upregulation of Na+/Ca2+ exchanger contributes to the enhanced Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Am J Physiol Cell Physiol 292:C2297-305
Dong, Hui; Smith, Anders; Hovaida, Marjan et al. (2006) Role of Ca2+-activated K+ channels in duodenal mucosal ion transport and bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol 291:G1120-8
Smith, Anders J; Chappell, Alfred E; Buret, Andre G et al. (2006) 5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury. FASEB J 20:2486-95
Barrett, Kim E (2005) A new twist on trefoils. Focus on ""TFF3 modulates NF-{kappa}B and a novel regulatory molecule of NF-{kappa}B in intestinal epithelial cells via a mechanism distinct from TNF-{alpha}"". Am J Physiol Cell Physiol 289:C1069-71
Zhang, Shen; Yuan, Jason X-J; Barrett, Kim E et al. (2005) Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol 288:C245-52
Sellers, Zachary M; Childs, Debbie; Chow, Jimmy Y C et al. (2005) Heat-stable enterotoxin of Escherichia coli stimulates a non-CFTR-mediated duodenal bicarbonate secretory pathway. Am J Physiol Gastrointest Liver Physiol 288:G654-63
Dong, Hui; Sellers, Zachary M; Smith, Anders et al. (2005) Na(+)/Ca(2+) exchange regulates Ca(2+)-dependent duodenal mucosal ion transport and HCO(3)(-) secretion in mice. Am J Physiol Gastrointest Liver Physiol 288:G457-65
Tuo, Bi-Guang; Sellers, Zachary M; Smith, Anders J et al. (2004) A role for CagA/VacA in Helicobacter pylori inhibition of murine duodenal mucosal bicarbonate secretion. Dig Dis Sci 49:1845-52
Barrett, Kim E (2004) Mechanisms for amplified mediator release from colonic mast cells: implications for intestinal inflammatory diseases. World J Gastroenterol 10:617-9

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