Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK034574-08
Application #
3232878
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1983-12-01
Project End
1992-03-31
Budget Start
1991-05-01
Budget End
1992-03-31
Support Year
8
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Children's Memorial Hospital (Chicago)
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60611
Qu, Xiao-Wu; Thaete, Larry G; Rozenfeld, Ranna A et al. (2005) Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: Role of neuronal nitric oxide synthase. Crit Care Med 33:1050-6
Hsueh, Wei; Caplan, Michael S; Qu, Xiao-Wu et al. (2003) Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. Pediatr Dev Pathol 6:6-23
De Plaen, Isabelle G; Qu, Xiao-Wu; Wang, Hao et al. (2002) Endotoxin, but not platelet-activating factor, activates nuclear factor-kappaB and increases IkappaBalpha and IkappaBbeta turnover in enterocytes. Immunology 106:577-83
Wang, H; Qu, X; De Plaen, I G et al. (2001) Platelet-activating factor and endotoxin activate CCAAT/enhancer binding protein in rat small intestine. Br J Pharmacol 133:713-21
Rozenfeld, R A; Liu, X; DePlaen, I et al. (2001) Role of gut flora on intestinal group II phospholipase A2 activity and intestinal injury in shock. Am J Physiol Gastrointest Liver Physiol 281:G957-63
Tan, X D; Chang, H; Qu, X W et al. (2000) Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin. Br J Pharmacol 129:1522-9
Lendvai, N; Qu, X W; Hsueh, W et al. (2000) Mechanism for the isotype dependence of antibody-mediated toxicity in Cryptococcus neoformans-infected mice. J Immunol 164:4367-74
De Plaen, I G; Tan, X D; Chang, H et al. (2000) Lipopolysaccharide activates nuclear factor kappaB in rat intestine: role of endogenous platelet-activating factor and tumour necrosis factor. Br J Pharmacol 129:307-14
Qu, X W; Rozenfeld, R A; Huang, W et al. (1999) The role of xanthine oxidase in platelet activating factor induced intestinal injury in the rat. Gut 44:203-11
Qu, X W; Rozenfeld, R A; Huang, W et al. (1999) Roles of nitric oxide synthases in platelet-activating factor-induced intestinal necrosis in rats. Crit Care Med 27:356-64

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