Metabolic Control of Sugar Transport

Carruthers, Anthony

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK036081-12
• Application #: 2139721
• Study Section: Metabolism Study Section (MET)
• Project Start: 1985-09-25
• Project End: 1997-08-31
• Budget Start: 1996-09-01
• Budget End: 1997-08-31
• Support Year: 12
• Fiscal Year: 1996

Institution

• Name: University of Massachusetts Medical School Worcester
• Department: Biochemistry
• Type: Schools of Medicine
• DUNS #: 660735098
• City: Worcester
• State: MA
• Country: United States
• Zip Code: 01655

Publications

Ojelabi, Ogooluwa A; Lloyd, Kenneth P; De Zutter, Julie K et al. (2018) Red wine and green tea flavonoids are cis-allosteric activators and competitive inhibitors of glucose transporter 1 (GLUT1)-mediated sugar uptake. J Biol Chem 293:19823-19834

Lloyd, Kenneth P; Ojelabi, Ogooluwa A; Simon, Andrew H et al. (2018) Kinetic Basis of Cis- and Trans-Allostery in GLUT1-Mediated Sugar Transport. J Membr Biol 251:131-152

Lloyd, Kenneth P; Ojelabi, Ogooluwa A; De Zutter, Julie K et al. (2017) Reconciling contradictory findings: Glucose transporter 1 (GLUT1) functions as an oligomer of allosteric, alternating access transporters. J Biol Chem 292:21035-21046

Ojelabi, Ogooluwa A; Lloyd, Kenneth P; Simon, Andrew H et al. (2016) WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) Inhibits GLUT1-mediated Sugar Transport by Binding Reversibly at the Exofacial Sugar Binding Site. J Biol Chem 291:26762-26772

Sage, Jay M; Carruthers, Anthony (2014) Human erythrocytes transport dehydroascorbic acid and sugars using the same transporter complex. Am J Physiol Cell Physiol 306:C910-7

De Zutter, Julie K; Levine, Kara B; Deng, Di et al. (2013) Sequence determinants of GLUT1 oligomerization: analysis by homology-scanning mutagenesis. J Biol Chem 288:20734-44

Vollers, Sabrina S; Carruthers, Anthony (2012) Sequence determinants of GLUT1-mediated accelerated-exchange transport: analysis by homology-scanning mutagenesis. J Biol Chem 287:42533-44

Cura, Anthony J; Carruthers, Anthony (2012) Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasis. Compr Physiol 2:863-914

Cura, Anthony J; Carruthers, Anthony (2012) AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress. Am J Physiol Cell Physiol 303:C806-14

Mangia, Silvia; DiNuzzo, Mauro; Giove, Federico et al. (2011) Response to 'comment on recent modeling studies of astrocyte-neuron metabolic interactions': much ado about nothing. J Cereb Blood Flow Metab 31:1346-53