Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK036264-02
Application #
3234588
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1985-03-01
Project End
1988-02-29
Budget Start
1986-03-01
Budget End
1987-02-28
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Dentistry/Oral Hygn
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Griffin, Michael J; Wong, Roger H F; Pandya, Niyati et al. (2007) Direct interaction between USF and SREBP-1c mediates synergistic activation of the fatty-acid synthase promoter. J Biol Chem 282:5453-67
Latasa, Maria-Jesus; Griffin, Michael J; Moon, Yang Soo et al. (2003) Occupancy and function of the -150 sterol regulatory element and -65 E-box in nutritional regulation of the fatty acid synthase gene in living animals. Mol Cell Biol 23:5896-907
Moon, Yang Soo; Latasa, Maria-Jesus; Griffin, Michael J et al. (2002) Suppression of fatty acid synthase promoter by polyunsaturated fatty acids. J Lipid Res 43:691-8
Moon, Y S; Latasa, M J; Kim, K H et al. (2000) Two 5'-regions are required for nutritional and insulin regulation of the fatty-acid synthase promoter in transgenic mice. J Biol Chem 275:10121-7
Latasa, M J; Moon, Y S; Kim, K H et al. (2000) Nutritional regulation of the fatty acid synthase promoter in vivo: sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element. Proc Natl Acad Sci U S A 97:10619-24
Sul, H S; Latasa, M J; Moon, Y et al. (2000) Regulation of the fatty acid synthase promoter by insulin. J Nutr 130:315S-320S
Dircks, L K; Ke, J; Sul, H S (1999) A conserved seven amino acid stretch important for murine mitochondrial glycerol-3-phosphate acyltransferase activity. Significance of arginine 318 in catalysis. J Biol Chem 274:34728-34
Sul, H S; Smas, C M; Wang, D et al. (1998) Regulation of fat synthesis and adipose differentiation. Prog Nucleic Acid Res Mol Biol 60:317-45
Sul, H S; Wang, D (1998) Nutritional and hormonal regulation of enzymes in fat synthesis: studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription. Annu Rev Nutr 18:331-51
Wang, D; Sul, H S (1998) Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt. J Biol Chem 273:25420-6

Showing the most recent 10 out of 28 publications